Protein Alignment TRIB2 and nipi-3

DIOPT Version :10

• Sequence 1: NP_067675.1
• Gene: TRIB2 / 28951
• HGNCID: 30809
• Length: 343
• Species: Homo sapiens
• Sequence 2: NP_510573.3
• Gene: nipi-3 / 181650
• WormBaseID: WBGene00010700
• Length: 655
• Species: Caenorhabditis elegans
• Alignment Length: 318
• Identity: 70/318 - (22%)
• Similarity: 140/318 - (44%)
• Gaps: 48/318 - (15%)

Human    19 NKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETP-NLSHCVSCIGKYLLLEPLEGDH-VFRAVHL 81
            |:.:....:..:...|.|:.||.. .|.:|...| :..|.|:  |:.:.:..:.|.. |.|||..
 Worm   156 NENEYLRLIQELEEEEKSKQFSAT-SSSAPHVNPYSAQHLVN--GEIIGIFVIYGTGLVTRAVCS 217

Human    82 HSGEELVC---------KVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSY--- 134
            .:.|....         ||.|:  .:....|....|..::..:::|:.:.:....:.....|
 Worm   218 QTREMFTAHVLPEWKASKVIDV--IRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILM 280

Human   135 -----GDMHSF-VRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTR--V 191
                 ..:||: .....::.|.:...::.::...|..||...::|::.|.|.|..|.:...:  |
 Worm   281 NPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHSRKVILQNFKPRSFYLKKDAHNKWVV 345

Human   192 KLESLEDAYILRGDDD----SLSDKHGCPAYVSPEIL----NTSGSYSGKAADVWSLGVMLYTML 248
            :...|:|   :..::|    ..:.:..|..:::||:|    .|..|||   .::|.|||:||.:|
 Worm   346 RPCFLQD---MSCEEDQSEAQFTRRSVCVPFMAPEMLTAESRTHHSYS---TELWGLGVLLYILL 404

Human   249 VGRYPFHDIEPSSLFSKIR----RGQFNIPETLSPKAKCLIRSILRREPSERLTSQEI 302
            .|:||||:.....||..|:    |..||.   :|.|::.::..:|::.|:.|:..:::
 Worm   405 TGKYPFHENSMPLLFRTIKFKQHRWPFNF---ISSKSRNIVNMLLKKAPATRMNLEDL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB2	NP_067675.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..50		6/24 (25%)
		PK_TRB2	67..308	CDD:270924	59/269 (22%)
nipi-3	NP_510573.3	Protein Kinases, catalytic domain	208..459	CDD:473864	58/261 (22%)