Protein Alignment GRID2 and GluRIIC

DIOPT Version :9

• Sequence 1: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 225/916 - (24%)
• Similarity: 377/916 - (41%)
• Gaps: 192/916 - (20%)

Human    87 ATALPQKTCELMNQGILAL----------VSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRS 141
            :..:.:..|:|::.|:.|:          :.::.|.|.|          |||:....|..
  Fly    73 SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTG----------IPHIEFDISDE----- 122

Human   142 GCGLTRSNRNDDYTLSVRP-PVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGM 205
              |:.....|...||::.| ...|......:|..:.|:||.|.||:: |.|......|.:.
  Fly   123 --GIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDAD-DARAAARLQDLLQ---- 180

Human   206 DVALQKVENNINKMITTLFDTMRIEELNRYRDTL---------RRAILVMNPATAKSFITEVVET 261
               |::|.|          |.:|:.:.::..|..         ||.:|...|......:....|.
  Fly   181 ---LREVHN----------DVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEF 232

Human   262 NLVAFDCHWIIINEEINDVDVQEL--------VRRSIGRLTIIRQTFPVPQNISQRCFRGNHRIS 318
            .|.....|..:.|.|.....::||        |..:..||.:  ...|.|.::..........|.
  Fly   233 GLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLV--NPDPPPYSLPYGYVTQRDNIV 295

Human   319 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKK---LEDRKWHSMASLSCIRKNSKPWQGGRS 380
            ....||......::      |:|.:.|.|.::...   ..||......:........:.|..||.
  Fly   296 YESSDPPRTLIHDL------IHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRY 354

Human   381 MLETIKKGGVSGL------TGELEFGENGGNPNVHFEILGTNYGEELGRGVRKNERIRPQGSTGK 439
            :...:|  |.||:      |..|:|.|:|.....:.|:    |....|.|:             .
  Fly   355 LARLMK--GTSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIGI-------------A 400

Human   440 IWPQLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSE-----NVLGKPKKYQGFS 499
            ||...|   .:|.||   .|.|.:..|   :.||.|.:..|:...:|     |:.|. ..|||::
  Fly   401 IWDPRG---QITQLN---VDVKAQKKM---IYRVATRIGPPYFSYNETARELNLTGN-ALYQGYA 455

Human   500 IDVLDALSNYLGFNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 563
            :|::||::.::||.|......|.:||. .:|...|||::||::...|.:||..||||..|:..||
  Fly   456 VDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVD 520

Human   564 FTTRYMDYSVGVLLRRA---EKTVDMFACLAPFDLSLWACIAGTVLLVGLL------VYLLNWLN 619
            ||..:|...|.:|..::   |||:|  |.||||...:|..|..:|.::..|      :..::|.|
  Fly   521 FTVPFMQLGVSILAYKSPHVEKTLD--AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN 583

Human   620 P------PRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 678
            |      |.:.....   .::|:.|....|.:..|.::...:...||....||:||:|:.:||||
  Fly   584 PHPCNRDPEVLENQW---RIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTA 645

Human   679 NLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRS 743
            |||||||.:::|.||.:|:|||.|.::.:||:...:.|      .|.....:::|...:.::|..
  Fly   646 NLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTY------NLLADSNETVYRLAFNLMNND 704

Human   744 NGS---ENNVLESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQ 803
            :.|   ::|:    .|:.:|:  .|:|.|:.:...|||  ..:.:|...::|....::.|.||:.
  Fly   705 DPSAYTKDNL----EGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVP 763

Human   804 HGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA 868
            .|:.||...|..||:|.:.|::..||.||| ||.....:...|...... :..:...|:|..|.|
  Fly   764 FGAEYRSNLSVAILKLSERGELYDLKQKWW-KNPNASCFEEPDPDATPD-MTFEELRGIFYTLYA 826

Human   869 GIVLSCFIAMLE--------------TW--------------WNKRK----GSRV------PSKE 895
            ||:::..|.:.|              |:              ||.||    |:.:      |.:.
  Fly   827 GILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRS 891

Human   896 DDKEID 901
            .||.:|
  Fly   892 LDKSLD 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRID2	XP_011530195.2	None
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	76/392 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	15/91 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	121/389 (31%)
		Lig_chan	554..828	CDD:278489	79/290 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.790