DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRID1 and Nmdar1

DIOPT Version :9

Sequence 1:NP_060021.1 Gene:GRID1 / 2894 HGNCID:4575 Length:1009 Species:Homo sapiens
Sequence 2:NP_730940.1 Gene:Nmdar1 / 40665 FlyBaseID:FBgn0010399 Length:997 Species:Drosophila melanogaster


Alignment Length:1067 Identity:245/1067 - (22%)
Similarity:442/1067 - (41%) Gaps:214/1067 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    22 SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEAN-NPFQAVQEACD-LMT 84
            |..:||.:...:.:::.  |...:..|:.:...: ..|:||..|.|..: ||.:.|...|| |:.
  Fly    37 STYNIGGVLSNSDSEEH--FSTTIKHLNFDQQYV-PRKVTYYDKTIRMDKNPIKTVFNVCDKLIE 98

Human    85 QGILALVTS----TGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRP 145
            ..:.|:|.|    :|..|..|:...:....||.:.:............|::        .|.:.|
  Fly    99 NRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVS--------FLRTVP 155

Human   146 P-VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL--------QSFLDQAS-RLGLDVSLQKVDKN 200
            | ....||.|.:::...:.|.::.:.|:.|.|.:        |::.|... |..:::.::...|.
  Fly   156 PYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKL 220

Human   201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEI--- 262
            .|  ||.....|||.:...|       ::..|.:.|.....:|.|.|:..:...|:...:.:   
  Fly   221 ES--FTEHLIDMKTAQSRVY-------LMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSN 276

Human   263 SDPE-ILDL----VHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLY 322
            :.|: :|.|    .||..|                                             :
  Fly   277 NTPDGVLGLQLEHAHSDKG---------------------------------------------H 296

Human   323 LYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDS 387
            :.|||.:||:|. :::...:..:.|..:| ..|...|..|:.:...:|..:|||.||.:.|.::.
  Fly   297 IRDSVYVLASAI-KEMISNETIAEAPKDC-GDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNG 359

Human   388 SNPYVQFEILGTTYSE---TFGK----DMR---KLATWDSEKGLNGSLQERPMGSRLQGLTLKVV 442
            ...|..::::.....:   ..||    .||   ::...|||....|..:.:|.|..:. ..|:::
  Fly   360 DRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIP-THLRLL 423

Human   443 TVLEEPFVMVA----ENILGQPKR-----------------YKGFSIDVLDALAKALGFKYEIYQ 486
            |:.|:|||.|.    :....:|..                 .:|:.||:|..|:|.:.|.|::..
  Fly   424 TIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLAL 488

Human   487 APDGRYGHQL--HNT-------SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVG 542
            :|||::||.:  :||       .|.|:||||:::|||:.::.:||.|||...::|||.:....:.
  Fly   489 SPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGIT 553

Human   543 ILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR--AQSAAQPRPSASATL 605
            ||.|||....::.|...||...:|..:..::.||.:::::|:|.....  ..|.:......:..|
  Fly   554 ILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNL 618

Human   606 HSAIWIVYGAFVQQG-GESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQ 669
            .||:|..:|..:..| ||.:..|.:.|::...|..|.:|:.:||||||||||.:.|....:....
  Fly   619 SSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGIN 683

Human   670 D--LSKQVE-MSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRK 731
            |  |...:| ::..||:.|:|..|||        :....:.::||:..|..|     :..:.|:.
  Fly   684 DARLRNTMENLTCATVKGSSVDMYFR--------RQVELSNMYRTMEANNYA-----TAEQAIQD 735

Human   732 AKKGN-YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTG 795
            .|||. .||:||.:.:||.|  ..||.:...|......||||.||.|||:.|..:..|||..::|
  Fly   736 VKKGKLMAFIWDSSRLEYEA--SKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESG 798

Human   796 DLDVLKQKWWPH---MGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNS 857
            .::.|.::|..|   ...|:|     .:....:|.|.:.||||.::.:|:.....:..:|:.:..
  Fly   799 FMEKLDKQWIFHGHVQQNCEL-----FEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKK 858

Human   858 NRCHQETPKEDKEVNLEQ---------------------VHRRMNSLMDEDIAHKQISPASIELS 901
               ||  .|:.|.:::.:                     :.|:.|..::...|...||.|..:..
  Fly   859 ---HQ--VKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTISLAVDKRR 918

Human   902 ALEMGGLAPTQTLEPTREYQNTQLSVSTFLP--EQSSHGTSRTLSSGPSSNLPLPLSSSATMPSM 964
            ...:|     |.|.|.|.:......|.....  |..:.|.|..:.:.....:|:|:         
  Fly   919 YPRLG-----QRLGPERAWPGDAADVLRIRRPYELGNPGQSPKVMAANQPGMPMPM--------- 969

Human   965 QCKHRSPNGGLFRQSPVKTPIPMSFQP 991
                      |.:..|.::.:|..:.|
  Fly   970 ----------LGKTRPQQSVLPPRYSP 986

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRID1NP_060021.1 Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627 21..436 87/447 (19%)
PBP1_iGluR_delta_1 25..423 CDD:107387 83/431 (19%)
ANF_receptor 41..400 CDD:279440 74/382 (19%)
PBP2_iGluR_delta_1 436..806 CDD:270448 122/406 (30%)
Lig_chan 564..841 CDD:278489 83/286 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..954 4/25 (16%)
Nmdar1NP_730940.1 PBP1_iGluR_NMDA_NR1 12..405 CDD:107374 84/434 (19%)
ANF_receptor 58..371 CDD:279440 73/377 (19%)
PBP2_iGluR_NMDA_Nr1 417..818 CDD:270437 123/416 (30%)
HisJ 451..>558 CDD:223904 34/106 (32%)
Periplasmic_Binding_Protein_Type_2 <516..651 CDD:304360 39/134 (29%)
Lig_chan 575..838 CDD:278489 83/282 (29%)
CaM_bdg_C0 854..882 CDD:287524 4/32 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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