DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRID1 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	910	Identity:	221/910 - (24%)
Similarity:	387/910 - (42%)	Gaps:	145/910 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     6 LWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEAN 70
            :|...::|:....:    |:|||.|.::..:.::.|...|:.:: ..:..|:.:....||.::..
  Fly    11 MWSAFFMCRSRGQQ----INIGAFFYDDELELEKEFMTVVNAIN-GPESEQTMRFYPLIKRLKPE 70

Human    71 NPFQAVQE-ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGG----SPRTACHL 130
            :....:|| ||||:..|:.|:...:..|:::.:..:.::..|||:....:..|    .|.....|
  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTL 135

Human   131 NPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQ 195
            |..|   |..:.|:       ....:|....|:||.:.||:: |.|.       |:||...:.|:
  Fly   136 NLYP---AQAILSK-------AYADIVQNFGWRKFTIVYDAD-DARA-------AARLQDLLQLR 182

Human   196 KVDKNISHV--------FTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKD 252
            :|..::..|        |..::.:::.|         ||.:|...|......:|.:.|..|..:.
  Fly   183 EVHNDVVRVRKFHKDDDFRVMWKSIRGE---------RRVVLDCEPNMLVELLNSSTEFGLTGQY 238

Human   253 SHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQE------- 310
            :|....|.|.....:.:|                 |.||:... .|...:.||.:|..
  Fly   239 NHIFLTNLETYTDHLEEL-----------------AADNETFA-VNITAARLLVNPDPPPYSLPY 285

Human   311 GYLQMLQISNLYLYDSVLMLANAFHRKLED------RKWHS----------MASLNC--IRKSTK 357
            ||  :.|..|: :|:|........|..:.|      :.|.:          :..:.|  .....:
  Fly   286 GY--VTQRDNI-VYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGR 347

Human   358 PWNGGRSMLDTIKKGHITGL------TGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWD 416
            .|..|| .|..:.|| .:|:      |.:::|.||........|:    |....|..   :|.||
  Fly   348 TWAMGR-YLARLMKG-TSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIG---IAIWD 403

Human   417 SEKGLNGSLQERPMGSRLQ-GLTLKVVTVLEEPFVMVAE-----NILGQPKRYKGFSIDVLDALA 475
            .    .|.:.:..:..:.| .:..:|.|.:..|:....|     |:.|. ..|:|:::|::||:|
  Fly   404 P----RGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGN-ALYQGYAVDLIDAIA 463

Human   476 KALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDY 539
            :.:||:|......|.:||.....| .|||:|||:|:..|.:.|..:|||..|::.|||:..:|..
  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528

Human   540 SVGIL-IKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRP---- 599
            .|.|| .|.|..:.::.:..|||...||..|..::.|:..|..::.||..:..::   |.|
  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN---PHPCNRD 590

Human   600 ----SASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660
                .....:|:..|:...:.:..|.:....|..:|:...:||:|.:|:.:|||||||||||.|:
  Fly   591 PEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSK 655

Human   661 MDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSP 725
            |:..|...:|||.|.::.:||:...:.|...       .:.:.|...|...:..|..........
  Fly   656 MEGSIANLKDLSAQKKVKFGTIYGGSTYNLL-------ADSNETVYRLAFNLMNNDDPSAYTKDN 713

Human   726 SEGIRKAKK--GNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRI 788
            .||:.:.:|  |:|.||.:...:||.  .:.:|.:..:|.....|.|.||:..|:.||...|..|
  Fly   714 LEGVDRVRKNRGDYMFLMETTTLEYH--REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAI 776

Human   789 LELQDTGDLDVLKQKWWPH-MGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE 852
            |:|.:.|:|..||||||.: ...|.......|..|   :......|:|..|..|:|:|.|:...|
  Fly   777 LKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD---MTFEELRGIFYTLYAGILIAFLIGITE 838

Human 853 852
Fly 839 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		92/459 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	89/441 (20%)
		ANF_receptor	41..400	CDD:279440	80/402 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	115/386 (30%)
		Lig_chan	564..841	CDD:278489	78/287 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	88/435 (20%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	16/88 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	115/383 (30%)
		Lig_chan	554..828	CDD:278489	78/288 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840