DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRID1 and Ir8a

DIOPT Version :9

Sequence 1:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	1025	Identity:	221/1025 - (21%)
Similarity:	380/1025 - (37%)	Gaps:	320/1025 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   142 ASRPPVRLNDVMLRLVTE---LRWQKF----------------VMFYDSEYDI------------ 175
            |.|..|:::|..|.|...   |..|:|                ...::..|::
  Fly    47 ALRLDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRSLGIGYVRLE 111

Human   176 RGLQSFLDQASRLGLDVSLQKVDKNISHVF--------------------TSLFTTMKTEE---- 216
            |.::.|||...    |...||...|::.||                    |.:....:|:.
  Fly   112 RIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHF 172

Human   217 LNRYRDTLRRA---ILLLSPQGAHSFINEAVE-TNLASKDSHWVFVNEEISD------------- 264
            |.|.| :||.|   |.|.:...|.:.|.|.|: .:|..:...|.||..:..|
  Fly   173 LERIR-SLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTRDRVFKYRRQAELCT 236

Human   265 ---------------PEI-----LDLVHSALGRMTVVRQIFPSAKDN--------QKCTRNNHRI 301
                           |::     ..:..:.|  :.|:|.:..:|:.:        |.|  |....
  Fly   237 RFTLNPRAICRSMPMPDLYCGSGFTMQRAML--LNVLRSLINAAQVSPGYPLAIYQDC--NATAS 297

Human   302 SSLLCDPQE----GYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGG 362
            ||.:.||.|    .:|.|:..||...|...|       ..::|:           .:|..|   |
  Fly   298 SSEVSDPLEKDDYNWLDMVHWSNFLAYAPPL-------PHIQDQ-----------FQSPVP---G 341

Human   363 RSMLDTIKKGHIT------------GLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATW 415
            .:....|..|:.:            ...|.|....::.:|..:|..:||..|          ..|
  Fly   342 LTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIGTAES----------IPW 396

Human   416 D---SEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKA 477
            .   .|:|....:::|      .||.:                       ::|:.||.:..|::.
  Fly   397 SYLRREEGTGELIRDR------SGLPI-----------------------WEGYCIDFIIRLSQK 432

Human   478 LGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYS-V 541
            |.|::||.....|..|.......|:|::|:|:....|.||:|:.:..|||.|:||...|.:.: :
  Fly   433 LNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGI 497

Human   542 GILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSA--SAT 604
            .|.|:||..:.|:|.........||..|.||:....::|:.:::.....:::..|..|.|  ..|
  Fly   498 SIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYACREFT 562

Human   605 LHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQ 669
            |..:.|....:|..|||..:..:::.|:::.::|||.:::.:::||||||||||.||..|:::.:
  Fly   563 LRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE 627

Human   670 DLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGAD--------------- 719
            .|::|..::|..|:||..::||    .|....:.|...:|:.::.|...|
  Fly   628 QLARQSRINYTVVKDSDTHQYF----VNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQY 688

Human   720 ----NCVSSPSEGIRKAKKG----------NYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGY 770
                ..::| |:.:..||:|          :|||:.|.|.::|....  :|::|.:|...:.:.|
  Fly   689 GHILLAINS-SQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITR--NCNLTEVGEVFAEQPY 750

Human   771 GIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWW--PHMGRCDLTSHASAQADGKSLKLHSFAG 833
            .:|:|.||...|..|..|||||.....:.||.|:|  .::..|.|:.      |.:.:.|.|..|
  Fly   751 AVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSE------DQEGITLESLGG 809

Human   834 VFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASI 898
            ||.....||:||.:...:|:.:...:
  Fly   810 VFIATLFGLVLAMMTLGMEVLYYKKK--------------------------------------- 835

Human   899 ELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSAT--- 960
                                  ||. |.::...|...|.|     |.|.||..| |.::|.|
  Fly   836 ----------------------QNA-LEITQVRPVNDSSG-----SGGNSSTAP-PTATSTTKQA 871

Human   961 --MPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVP--GGVLPEALDTSHG 1006
              :|.::.:          :.|.|...|.||:...  |..||..:....|
  Fly   872 WHIPVLEAE----------EKPAKVSPPPSFETATFRGKKLPARITLGDG 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		75/412 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	74/399 (19%)
		ANF_receptor	41..400	CDD:279440	69/373 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	109/403 (27%)
		Lig_chan	564..841	CDD:278489	84/309 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954		8/23 (35%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	116/448 (26%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	84/310 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810