DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA4 and KaiR1D

DIOPT Version :9

Sequence 1:NP_000820.4 Gene:GRIA4 / 2893 HGNCID:4574 Length:902 Species:Homo sapiens
Sequence 2:NP_650925.1 Gene:KaiR1D / 42473 FlyBaseID:FBgn0038837 Length:853 Species:Drosophila melanogaster


Alignment Length:874 Identity:347/874 - (39%)
Similarity:511/874 - (58%) Gaps:82/874 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    22 AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAP-FNLVPHVDNIETANSFAVTNAFCS 85
            :.|..::|||||....|.:..|||.|:  ...:.:.|..| ..||..::.|...:||......|.
  Fly    25 SLPDIIKIGGLFHPADDHQELAFRQAV--DRINADRSILPRSKLVAQIERISPFDSFHAGKRVCG 87

Human    86 QYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLR------------PSL 138
            ..:.||.||||.....:...:.|.|..:.|..:        |:::..:||            .:|
  Fly    88 LLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL--------ENRWDYRLRRESCLVNLYPHPNTL 144

Human   139 RGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203
            ..|.:.::.|:.|..|..:|:.:.|...||.:::..|...:.::...:.:..|  ||.||:::..
  Fly   145 SKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSDSGD--YRPLLKQIKN 207

Human   204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYH-YIIANLGFKDISLERFIHGGANVTGFQLVDF 267
            ..|...|:||..||:..:|:|...:|. :..|| |::.:|....::|:.|.:||.|:|||:|:  
  Fly   208 SAEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI-- 269

Human   268 NTPMVIKLMDRWKKLDQREYPGSE--TPPKYTSALTYDGVLVMAETFRSL-RRQKIDISRRGNAG 329
            |..:|..::.:| .:|::....|.  |..:..:||.||.|.:.|:....| ..|:|||......|
  Fly   270 NEKIVSDVVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDG 333

Human   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMD 394
            .      :.|..|..:...:|.|.::|||..::|||.|.|.::.:|:.||...|.||:|.||   
  Fly   334 Q------STWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN--- 389

Human   395 KLVLIQDVPTLGNDT-----------AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCV 448
                 ..:|...|.|           |.::|:|:|||||:.:||.|.|::.....|||::|||.|
  Fly   390 -----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAV 449

Human   449 DLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDF 513
            ||..||:|.:|..|||.:||||.||:.:..|..||||:.||:..:|::|||.||||..||:.:||
  Fly   450 DLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDF 514

Human   514 SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW----- 573
            :.|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||     
  Fly   515 TTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTD 579

Human   574 -HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISS 637
             |.|:.|           ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||
  Fly   580 AHGEKVE-----------SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISS 633

Human   638 YTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPS 702
            ||||||||||||||.|||||||||||||.|.||.|..|||..|||.|||:.|::||::|.||.||
  Fly   634 YTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPS 698

Human   703 VFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTP 767
            |||.:..|||.||.|.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..||.
  Fly   699 VFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTA 762

Human   768 VNLAVLKLSEAGVLDKLKNKWWYDK---GECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAM 829
            :|..:|||.|.|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.
  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827

Human   830 LVALIEFCYKSRAEAKRMKLTFSEAIRNK 858
            ::|:.||.:|||..|...:|:   ||.|:
  Fly   828 VIAVCEFVWKSRKVAVEERLS---AILNE 853

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA4NP_000820.4 PBP1_iGluR_AMPA_GluR4 28..398 CDD:107383 106/386 (27%)
PBP2_iGluR_AMPA_GluR4 414..795 CDD:270445 210/389 (54%)
Glutamate binding. /evidence=ECO:0000250 500..502 0/1 (0%)