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Protein Alignment GRIA4 and Ir64a

DIOPT Version :9

Sequence 1:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	127/696 - (18%)
Similarity:	225/696 - (32%)	Gaps:	213/696 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   291 ETPPKYTSALTYDGVLVMAETF----RSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQ 351
            |.||......|.|..|...|:|    ......::.:::|       .:.||.:        ||..
  Fly   214 EEPPGQQIQATDDEDLPSIESFLGGMNLYMNTELTLAKR-------MSEAAHY--------TLFD 263

Human   352 VRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENR- 415
            |...||       :||..||.|            ::|.:...:.:.|    .|....|:.:..|
  Fly   264 VWNPGL-------NYGGHVNLT------------EIGSFTPTEGIQL----HTWFRTTSTVRRRM 305

Human   416 ---------TVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIA------ 465
                     .||||....:..:||...|.|....|....:..:|...:.......:.::
  Fly   306 DMQHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWG 370

Human   466 IVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 530
            .|.:|::          :||:|.|:..:.:|..||:...|.|.:.||.:....|.....:.:.|:
  Fly   371 YVKNGRF----------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPR 425

Human   531 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEW--------------------- 573
            .::.....||.|...::|:.||    |..|: :|::...:..||
  Fly   426 STQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRH 486

Human   574 --------------------------------HTEEPEDG----------------------KEG 584
                                            ..||.||.                      ::.
  Fly   487 HYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKA 551

Human   585 PSDQPPNEFGIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 648
            ...:.|...|:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|::...|.:
  Fly   552 KQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLM 616

Human   649 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVA 713
            |: ...|::..||. .:.:..|..|....:::|..:|..|..:::....::.|     ||.|..|
  Fly   617 EK-PKTIKTLSDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVP-----TTKENEA 674

Human   714 ---------RVRKSKGK-----------------------------------FAFLLE-----ST 729
                     .|.....|                                   |||.::     ..
  Fly   675 DEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKI 739

Human   730 MNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGE 794
            :.|...::..||..:|......|...: ..|.|.:|..::..:.:::|.|:|....|.|...|..
  Fly   740 IAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPP 803

Human   795 CGPKDSGSKDKTSAL--SLSNVAGVFYILVGGLGLAMLVALIEFCY 838
            |     ..|.:||.|  .:..|:....||:....:.:::...|..|
  Fly   804 C-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.