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Protein Alignment GRIA4 and Ir8a

DIOPT Version :9

Sequence 1:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	877	Identity:	206/877 - (23%)
Similarity:	351/877 - (40%)	Gaps:	227/877 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   191 DVSYRQLLEELDRRQEKKFVIDCEIE-------------RLQNILEQIVSVGKHV---------- 232
            |.....:|:|||..:     :|.:::             .:|...|.:.:||...
  Fly    35 DTDIAMVLKELDALR-----LDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWE 94

Human   233 KGYHYIIANLGFKDISLERFIHGGANVTGFQLVDF-------NTPMV-IKLMDRWKKLDQR--EY 287
            :||: ::.:||...:.|||.:....::.|    ||       |..|| :...|..:.:.|.  .|
  Fly    95 EGYN-LVRSLGIGYVRLERIMRPFLDMFG----DFMRQKRANNVAMVFMNARDAVEAMQQMLVGY 154

Human   288 P-------GSETPP---------KYTSALTYDGVLVMAETFRSL--RRQKIDISR---------- 324
            |       .|:|.|         ....|.||..:...|.....:  :.||.|:.:
  Fly   155 PFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFL 219

Human   325 ---------RGNAGDC---LANPAA-----PW-----GQGIDMERTLKQVRIQGLTGNVQ----- 362
                     |..|..|   ..||.|     |.     |.|..|:|.:....::.|....|
  Fly   220 DTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGY 284

Human   363 ------------------------------------FDHYGRRVNYTMDVFELKSTGPR-----K 386
                                                |..|...:.:..|.|:....|..     .
  Fly   285 PLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNIS 349

Human   387 VGY-------------WNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFE 438
            .||             |:.:.::.|:       |:|.:...|...:.|....|:...::.....|
  Fly   350 AGYYSSEHEAKTDLAAWSSVGEMRLL-------NETISPARRFFRIGTAESIPWSYLRREEGTGE 407

Human   439 ------GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIA 497
                  |...:||||:|....:::.:..:::|.....|..|..: :...|:|:||:||.|:.:.|
  Fly   408 LIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFA 471

Human   498 IAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 561
            ||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::
  Fly   472 IAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIM 535

Human   562 LFLVSRFSPYEWHTEEPEDGKEGPSDQP--PNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 624
            ::.:.::|||        ..:......|  ..||.:..|.||:|.:|..||...:|:::|||::.
  Fly   536 IWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLV 592

Human   625 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA-- 687
            ..:|.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.|
  Fly   593 AAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAED 657

Human   688 -VYE----------------KMWTY------------MRSAEPSVFTRTTAEGVARV-RKSKGKF 722
             :|.                ::|.|            :.|::|   .....||.|.| ......:
  Fly   658 TLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADY 719

Human   723 AFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK 787
            ||:.:|...:| |..:.|:..:||.....:.|.||..:||.|...::.|:|:|.:....::||.|
  Fly   720 AFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAK 783

Human   788 WWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFS 852
            :|.....  |....|:|: ..::|.::.|||...:.||.|||:...:|..|..:.: ..:::|
  Fly   784 YWNQSNL--PNCPLSEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQ-NALEIT-- 842

Human   853 EAIRNKARLSITGSVGENGRVLTPDCPKAVHT 884
             .:|     .:..|.|..|...|.. |.|..|
  Fly   843 -QVR-----PVNDSSGSGGNSSTAP-PTATST 867

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.