Protein Alignment GRIA3 and GluRIB

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 960
• Identity: 410/960 - (42%)
• Similarity: 549/960 - (57%)
• Gaps: 160/960 - (16%)

Human    34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGV 98
            |.:|.:|.:.|.:..|||::|  :.|.|.|.:.:.|.|..:||.::::::|.::...|:||||||
  Fly    42 IPLGAIFEQGTDEVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 104

Human    99 YAIFGFYDQMSMNTLTSFCGALHTSFVTPSF------PTDADVQFVIQMRPALKGAILSLLGHYK 157
            |::.|.....|.:||.|:.......||||.|      |:...:.|.:.|||....||:..:..|.
  Fly   105 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQFYG 169

Human   158 WEKFVYLYDTERGFSILQAIMEAAVQNN--WQV-TARSVGNIKDVQEFRRIIEEMDRRQEKRYLI 219
            |.|.:||||:..|...||.|.:.....|  :|| ..:.:.|:....||...:|::.|.:.|..::
  Fly   170 WRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVL 234

Human   220 DCEVERINTILEQVV---ILGKHSRGYHYMLANLGFTDILLERVMHGGA-NITGFQIVNNENPMV 280
            ||..|....||.|.|   .||:  |.|||:|:.|...|.....::..|| |||||:||:....:|
  Fly   235 DCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLV 297

Human   281 QQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVD-----VSRR------ 334
            ::|...|.|||.:....|....:...:||.:||:.|:.|||..:.|::.|     |.||
  Fly   298 REFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMV 362

Human   335 ------------------------------------GSAG------DCLANPAV----PWSQGID 353
                                                ||.|      ||  |.|.    .|..|..
  Fly   363 AQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC--NTAKGWVNAWEHGDK 425

Human   354 IERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSR-KAGYWNE----------YERFVP 407
            |.|.|:.|:::|:||:|:|:..|||.|||:.|.||.|:.:. |...||:          |.|..|
  Fly   426 ISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRP 490

Human   408 FSDQQISNDSASSENRTIVVTTILESPYVMYKK--NHEQLEGNERYEGYCVDLAYEIAKHVRIKY 470
            ..:.:        :|||.:|||:||.||:|.|:  ..|:|.||.|:||||.|||..:||.:.|.|
  Fly   491 HVEFE--------KNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINY 547

Human   471 KLSIVGDGKYGARDPETK-IWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI 534
            :|.:|.||.||:...... .|:|||||||...||||:|.:|||..||.|||||||||||||||||
  Fly   548 ELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMI 612

Human   535 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQS---- 595
            |||.|..||||||::||:.|||:.::|:|||||:|||.||||||:||.|.  .::|:..||
  Fly   613 KKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLV--QQQPQQSQSPDPH 675

Human   596 ----------------------PPDPP--------------------------------NEFGIF 606
                                  ||.||                                |||.::
  Fly   676 AHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVW 740

Human   607 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 671
            ||.||||.||||||||:||||:||||....|:|||||:||||||||||||||||||:||.|.|||
  Fly   741 NSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDL 805

Human   672 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL 736
            |.|||:.||||..|||.:|||||:|.::.|||.||.|.: .||..|..:|:.|||.||||:|.|:
  Fly   806 AMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLV 869

Human   737 ESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYD 801
            ||..|||:..|:||||||||.|||:||:|:|||.||||::.:|||||.|.|.|.|.||:|||||:
  Fly   870 ESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYE 934

Human   802 KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 851
            |.|| |...|.:...|.||||||||:||||:|||.:::.||::|:|::||
  Fly   935 KAEC-STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSR 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	139/454 (31%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	244/443 (55%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	136/442 (31%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	244/443 (55%)
		Lig_chan	630..966	CDD:459656	180/339 (53%)