Protein Alignment GRIA3 and KaiR1D

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_650925.1
• Gene: KaiR1D / 42473
• FlyBaseID: FBgn0038837
• Length: 853
• Species: Drosophila melanogaster
• Alignment Length: 856
• Identity: 332/856 - (38%)
• Similarity: 510/856 - (59%)
• Gaps: 54/856 - (6%)

Human    31 PNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFS 95
            |:.|.|||||......:..|||.||...|.:::...:. .|...::.:...:||......|...:
  Fly    27 PDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRS-KLVAQIERISPFDSFHAGKRVCGLLN 90

Human    96 RGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQF-----VIQMRP---ALKGAILSL 152
            .||.||||.....:.:.:.|.|..:.    .|......|.:.     ::.:.|   .|..|.:.:
  Fly    91 IGVAAIFGPQSSHTASHVQSICDNME----IPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDI 151

Human   153 LGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRY 217
            :.|:.|:.|..:|:...|...||.:::|.....:.:|.|   .:.|..::|.:::::....|...
  Fly   152 VRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVR---QLSDSGDYRPLLKQIKNSAEAHI 213

Human   218 LIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQ 282
            ::||..|||:.:|:|...:|..|..:.|::.:|....:.|:...:||.|||||:::|.:  :|..
  Fly   214 VLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLINEK--IVSD 276

Human   283 FIQRWVRLDEREFPEAKN-APLKYTSALTHDAILVIAEAFRYL-RRQRVDVSRRGSAGDCLANPA 345
            .:::| .:||:....:.| ..::..:||.:||:.:.|:|...| ..|::|:......|..
  Fly   277 VVRQW-SIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS----- 335

Human   346 VPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWN-------EYE 403
             .|..|..:...:|:|:::|:|..|:||..|.||::.:|:.|:..:|.||.|.||       .:.
  Fly   336 -TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFT 399

Human   404 RFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRI 468
            |......|:|   .|:.:|:|:||||||.:||.|.|::...|.||:::|||.|||.:||:|.:..
  Fly   400 RTFSQKQQEI---EANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGF 461

Human   469 KYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 533
            .||:.:|.||.||:.:..|..||||:.||:..|||:|:|.||||..||:.:||:.|||:||:||:
  Fly   462 NYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSIL 526

Human   534 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--HLEDNNEEPRDPQSP 596
            .:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||  :.:.:.|:..
  Fly   527 YRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDAHGEKVE----- 586

Human   597 PDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 661
                ::|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:|||||||||||||||||
  Fly   587 ----SQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERM 647

Human   662 VSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR 726
            .|||||||||||||.|.||.|..|||..|||.|||:.|::|||:|:||.|||||.:..:||.||.
  Fly   648 DSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVA 712

Human   727 KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLL 791
            |.||.:|||:|||..||:.:|. |:..:|||.||:|.||:|||..|..|.|:|..:|||.|:|.|
  Fly   713 KGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKL 776

Human   792 DKLKNKWWYDK---GECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR-- 851
            ..||.|||.:|   |:|......|....:.|.|:||.|||.:|:||:|:|.::|:.||.:|||
  Fly   777 HILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKV 841

Human   852 AESKRMKLTKN 862
            |..:|:....|
  Fly   842 AVEERLSAILN 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	97/390 (25%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	207/387 (53%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..400	CDD:380605	96/385 (25%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:473866	204/379 (54%)