Protein Alignment GRIA3 and Ir84a

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 146/604 - (24%)
• Similarity: 246/604 - (40%)
• Gaps: 135/604 - (22%)

Human   305 YTSALTHDAILVIAEAFRYLRRQRVDV-SRRGSAGDCLA-------NPAVPWSQ----------- 350
            |.|..|  |:||:......:|||...| |..|...:.||       ..::|..|
  Fly    93 YGSPRT--AVLVLNSEHVLVRRQVFGVASEAGYFNNSLAWFILGSGRESLPVEQLIDQLLSGYRM 155

Human   351 GI--DIERALKMVQVQGMTGNIQFDTY--GRRTNYTIDVYEMKVSGSRKAGYWNE---YERFVPF 408
            ||  ||..||:......|   :.:|.|  .|:.|..:.:        .|.|.|..   |::|..|
  Fly   156 GIDADITVALRGPDNASM---LFYDVYRISRQANTPLII--------EKKGLWTHSGGYQKFGNF 209

Human   409 SDQQISNDSASSENRTIVVTTIL-ESP-------YVMYKKNHEQLEGNERYEGYCVDLAYEIAKH 465
            .:..:.. ..:..|.|::.:|:| |.|       |:...|..:||:..:|       ..|::.:.
  Fly   210 KNTWVIR-RRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQR-------KTYQLFQL 266

Human   466 VRIKYKLSIVGD--GKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 528
            |...:.||:...  .|:|.. .:...|:|::|::....||.||.|:...|.|:..:.:|....:.
  Fly   267 VERMFNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQ 330

Human   529 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP 593
            .|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|......::|:.
  Fly   331 NIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRLERMLSNMENR------- 387

Human   594 QSPPDPPNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANL 652
                        |:.:||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:
  Fly   388 ------------FSFVWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFI 436

Human   653 AAFLTVE--RMVSPIESAED--LAKQTE-IAYG-TLDSGSTKEFFRRSKIAVYEKMWSYMKSAEP 711
            ...|..|  |.:..:::..|  ||...| |:|. .:.:.::.:..|    .||.|  ...||.|.
  Fly   437 VGSLLSESARSIVNLQALYDSNLAIGMENISYNFPIFTNTSNQLVR----DVYVK--KICKSGEH 495

Human   712 SVFTKTTADGVARVRKSKGKFAF----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGY 764
            ::.  :...|..|:  .:|:|||          |||..|:|    .:.||..:|..||  ||
  Fly   496 NIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS--- 549

Human   765 GVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTS--ALSLSNVAGV 827
            |...||||..|..:..|:|.....|||.....||...:.:|      |..|||  .:.|.:.|..
  Fly   550 GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC------SLFKTSQAEVDLEHFAPA 608

Human   828 FYILVGGLGLAMMVALIEF 846
            .:    .|.|||:.:.:.|
  Fly   609 LF----ALALAMVASALVF 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	32/129 (25%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	101/416 (24%)
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	6/20 (30%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	19/74 (26%)
		Lig_chan	353..602	CDD:459656	72/294 (24%)