Protein Alignment GRIA3 and Nmdar1

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 951
• Identity: 249/951 - (26%)
• Similarity: 408/951 - (42%)
• Gaps: 197/951 - (20%)

Human    13 RAVFFLVLGLL--------GHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPF 69
            |.:|.|.:.||        .|:....|:|.:|||:...:..:||    |:..:.:.|.:....|.
  Fly    10 RPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEH----FSTTIKHLNFDQQYVPR 70

Human    70 HLNYH--VDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMS-------MNTLTSFCGA------ 119
            .:.|:  ...:|.:...:|.|.........|||:...::|.|       ::..:.|...
  Fly    71 KVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGIS 135

Human   120 ----------LHTSFV--TPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLY--DTERG 170
                      :|.||:  .|.:...|||.             |.:|.|:.:.|.:.::  ||: |
  Fly   136 SRDAAFSDKNIHVSFLRTVPPYYHQADVW-------------LEMLSHFAYTKVIIIHSSDTD-G 186

Human   171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEK--RYLIDCEVERINTILEQV 233
            .:||         ..:|.|:::..:..||:....:|.|.:.:.|.  .:|||.:..:
  Fly   187 RAIL---------GRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQ-------- 234

Human   234 VILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEA 298
                  ||.| .|.|:.....::....  |..|:||...|             |:..::..|  :
  Fly   235 ------SRVY-LMYASTEDAQVIFRDA--GEYNMTGEGHV-------------WIVTEQALF--S 275

Human   299 KNAP-----LKYTSALT-----HDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGID 353
            .|.|     |:...|.:     .|::.|:|.|.:.:.............||    .||.|..|..
  Fly   276 NNTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGD----SAVNWESGKR 336

Human   354 IERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDS- 417
            :.:.||...:.|.||.:.||..|.|.....||..::....:.......|:........:| |||
  Fly   337 LFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRI-NDSE 400

Human   418 ---ASSENRT---------IVVTTILESPYVMYKK------------------NHEQLEGNE-RY 451
               ...:.|.         :.:.||.|.|:|..::                  |:.....|| ..
  Fly   401 IIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCC 465

Human   452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYG---ARDPE-----TKIWNGMVGELVYGRADIAVAP 508
            .|||:||..|::|.:...|.|::..||::|   .|:..     .|.|.|::||||..|||:.|||
  Fly   466 RGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAP 530

Human   509 LTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 573
            |||...|.|.|:|||||...||:|:.|||.:|.. :.|||.|.:..:|:.::.:...|::||:|:
  Fly   531 LTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFSNTLWILVMVSVHVVALVLYLL 594

Human   574 SRFSP---YEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVG 634
            .||||   ::....|:|||           ....:.:::||:.|..:..|. :.:|||.|.|::|
  Fly   595 DRFSPFGRFKLSHSDSNEE-----------KALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLG 648

Human   635 GVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI 696
            .||..|.:||::||||||||||.:||   .:|.|..|........:...|:...|...:|||.
  Fly   649 MVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQ-- 711

Human   697 AVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDS 761
               .::.:..::.|.:.:. |....:..|:|.| ..||:.:|:..|| |..|.|:.:..|.....
  Fly   712 ---VELSNMYRTMEANNYA-TAEQAIQDVKKGK-LMAFIWDSSRLEY-EASKDCELVTAGELFGR 770

Human   762 KGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYD---KGECGSGGGDSKDKT-SALSLS 822
            .|||:...|||...:||.||:|:.:|.|.::||..:|.:.   :..|     :..:|| :.|.|.
  Fly   771 SGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC-----ELFEKTPNTLGLK 830

Human   823 NVAGVFYI----LVGGLGLAMMVALIEFCYKSRAESKRMKL 859
            |:||||.:    :.||:||    .:||..||.....|:.:|
  Fly   831 NMAGVFILVGVGIAGGVGL----IIIEVIYKKHQVKKQKRL 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	82/414 (20%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	135/428 (32%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	87/431 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	135/425 (32%)
		CaM_bdg_C0	854..882	CDD:402271	4/14 (29%)