Protein Alignment GRIA3 and Ir75c

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Alignment Length: 668
• Identity: 132/668 - (19%)
• Similarity: 244/668 - (36%)
• Gaps: 117/668 - (17%)

Human   245 YMLANLGFTDILLERVM--HGGANITGFQIVN--NENPMVQQFIQRWVRLDEREFPEAKNAPLKY 305
            |.|......:|.|..:|  |..:....|.:|.  |:|.:..|:|      |.:......|...:|
  Fly     7 YRLIVFNLLEINLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYI------DVQNPDNLANVHKEY 65

Human   306 TSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQV-QGMTGN 369
            .     |:.||....|..|...:.::....|:...|.|..:.|....:.....|:.|: :|...:
  Fly    66 L-----DSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQLFEGANLS 125

Human   370 IQFD-TYGRRTN----YTIDVYEMKVSGSRKAGYWN-----------------EYERFVPFSDQ- 411
            :..| ||..|.:    ...|||.   .||...|..|                 ||...:....:
  Fly   126 LNADVTYVSREDEERFILHDVYN---KGSHLGGKLNITVDQTLQCNRSHCQVKEYLSELHLRPRL 187

Human   412 QISNDSASSENRTIVVTTILESPYVMYKKNHEQLE----GNERYEGYCVDLAYEIAKHVR--IKY 470
            |...|.:|...|...:.::|.    :.....|.||    ..:.:......:...:..|.:  :.:
  Fly   188 QHRMDLSSVTFRLAALVSVLP----INSSEEELLEFLNSDRDSHMDSISRIGNRLIMHTQEILGF 248

Human   471 KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIK 535
            ||..:..|.:..:|    .:.|.:|.|....|::...|...:..|...:.............|.:
  Fly   249 KLHYIWCGTWSVQD----AFGGAIGMLTNESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFR 309

Human   536 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPP 600
            .|..:......||:|....:|.......|...|:|:::       :|||.:..:......|
  Fly   310 TPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMI-------FHLERHWMQRCLDFIP---- 363

Human   601 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SP 664
               .:.:|...|.||...||..:.|:|..||:.     |..:::.|....|....:.|..:: ||
  Fly   364 ---SLLSSCLISFGAACIQGSYLMPKSAGGRLA-----FIAVMLTSFLMYNYYTSIVVSTLLGSP 420

Human   665 IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI---------AVYEKMWSYMKSAEPSVFTKTTAD 720
            :.|  ::....::|..:||.|.....|.::.:         ::|::  ......:|:....:..:
  Fly   421 VRS--NIRTIQQLADSSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQ--KVESKRDPNSVWLSPEE 481

Human   721 GVARVRKSKGKFAFLLE-STMNEYIEQ----RKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNL 780
            ||.|||...| |.:..| |.|..::|:    |:..|..::....:|..||: ....|..|..:..
  Fly   482 GVIRVRDQPG-FVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLNSTYRQLLTQ 544

Human   781 AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNV--------AGVFYILVGGLGL 837
            ..:::.|.|:..| :::::            ||.|....|.|.|        |.:|..|:....|
  Fly   545 LQVRMLETGITSK-QSRFF------------SKTKLHTFSNSFVIQVGMEYAAPLFISLLVAYFL 596

Human   838 AMMVALIEFCYKSRAESK 855
            |:::.::|.|:...|:.|
  Fly   597 ALLILILEICWARYAKKK 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	40/190 (21%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	74/403 (18%)
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	43/203 (21%)