Protein Alignment GRIA3 and Ir75a

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 104/538 - (19%)
• Similarity: 208/538 - (38%)
• Gaps: 88/538 - (16%)

Human   352 IDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV-----PFSDQ 411
            ||.:.:....|:|....::.:..:....|..|...::.|:||.:.    ..:.||     ..|..
  Fly   129 IDADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEM----SCDPFVCRRTRHLSSL 189

Human   412 QISNDSASSENRTIVV----TTILESPYV---------MYKKNHEQLEGNERYEGYCVDLAYEIA 463
            |..:...:.|..|.||    |.:.:.|..         :.::|...::...|: |:.:.|.....
  Fly   190 QKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARF-GFHLTLILRDL 253

Human   464 KHVRIKY-------KLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDF 521
            .|.::|:       |..:||               |.||.:|...||:...|   :|..|..:.:
  Fly   254 LHCKMKFIFSDSWSKSDVVG---------------GSVGAVVDQTADLTATP---SLATEGRLKY 300

Human   522 SKPFMSLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPY 579
            ....:..|.  |:.| :.|..:......||.|.:..:|...  |.:.|||.  :..::..:....
  Fly   301 LSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQK 365

Human   580 EWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 644
            .|.|:         ..|       .:.::...|.||...|...:.|||..||::....:..:.|:
  Fly   366 RWRLD---------YLP-------SLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISFIM 414

Human   645 ISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSK---IAVYEKMWSYM 706
            .:.||:.:.:.|....:.|.|::...|| ::.:..|......||.:...|:   |.::.|.....
  Fly   415 YNYYTSVVVSSLLSSPVKSKIKTMRQLA-ESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIES 478

Human   707 KSAEPSVFTKTTADGVARVRKSKGKFAFLLEST-----MNEYIEQRKPCDTMKVGGNLDSKGYGV 766
            ::..|.::. ....||.|||.:.| :.::.|::     :..|...::.||..:|....:...| .
  Fly   479 QTQNPELWL-PAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-T 540

Human   767 ATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYIL 831
            ...:.|..:....|..|::.|.|:..|.::.|.:.|..|     .:::....:.:..||.:..:|
  Fly   541 HLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHC-----VAQNFVITVGMEYVAPLLLML 600

Human   832 VGGLGLAMMVALIEFCYK 849
            :....|.:::.|:|..:|
  Fly   601 ICADILVVVILLVELAWK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	11/61 (18%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	82/417 (20%)
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	24/119 (20%)