Protein Alignment GRIA3 and GluRIA

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 896
• Identity: 382/896 - (42%)
• Similarity: 538/896 - (60%)
• Gaps: 90/896 - (10%)

Human    34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGV 98
            |.:|.:|.:.|....|||::|  :.|.|.|.:.:.|.|..:||.::::::|.::...|:||||||
  Fly    40 IPLGAIFEQGTDDVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 102

Human    99 YAIFGFYDQMSMNTLTSFCGALHTSFVTPSF------PTDADVQFVIQMRPALKGAILSLLGHYK 157
            |::.|.....|.:||.|:.......||||.|      |:...:.|.|.|||....||:..:.:|.
  Fly   103 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYG 167

Human   158 WEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQ---EFRRIIEEMDRRQEKRYLI 219
            |:..:||||:..|...||.|.:.....|.....:.|..|.:|.   ||...:|::.|..:||.::
  Fly   168 WQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVL 232

Human   220 DCEVERINTILEQVV---ILGKHSRGYHYMLANLGF-----TDILLERVMHGGANITGFQIVNNE 276
            ||..|....|:.|.|   .||:  |.|||:|:.|..     :|:    |..|..|||||:||::.
  Fly   233 DCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV----VEFGAINITGFRIVDSN 291

Human   277 NPMVQQFIQRWVRLDEREFPEAKNA-------PLKYTSALTHDAILVIAEAFRYLRRQRVD---- 330
            ...|:.|.....||:.....:::||       .:...:||.:||:.|:.|||..:.|::.|
  Fly   292 RRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRS 356

Human   331 --VSRRGSAG----------------DCLANP--AVPWSQGIDIERALKMVQVQGMTGNIQFDTY 375
              :.||...|                ||..:.  ..||.||..|.|.|:.|::.|::|.|:||..
  Fly   357 NHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDED 421

Human   376 GRRTNYTIDVYEMKVSGS-RKAGYWNEYERFVPFSDQQISNDSASS--------ENRTIVVTTIL 431
            |||.|||:.|.||.|:.: ::...|.:....:|......::.|.|:        .|.|.:|:::|
  Fly   422 GRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLL 486

Human   432 ESPYVMYKK--NHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IWNGM 493
            |.||:..|:  ..|.|.||:|:||||.|||..:|..:.|||::.:|.||.|||.:.... .|:||
  Fly   487 EEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGM 551

Human   494 VGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 558
            ||||:...||||::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||:.
  Fly   552 VGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWIS 616

Human   559 IVFAYIGVSVVLFLVSRFSPYEWHL------EDNNEEP---------RDPQS--PPDPPNEFGIF 606
            ::.:|:|||.||:.|:||.||||.:      :...::|         .:||:  ||.|||||.:.
  Fly   617 VILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTML 681

Human   607 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 671
            ||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::.|||
  Fly   682 NSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDL 746

Human   672 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL 736
            ..||::.||||..|||.||||||:|.::.|||.|| :|.......|..:|:.|||:||||:|.|:
  Fly   747 TMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLV 810

Human   737 ESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYD 801
            ||..|||:..|.||||||||.|:|:||:|||||.||.||..:|.|||.|.|.|.|.:::||||:|
  Fly   811 ESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD 875

Human   802 KGECGSGGGDSKDKT-SALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 851
            |.||..   |.:..| :.||||||||::|||:|||.||::||::||..:::
  Fly   876 KTECNL---DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNK 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	131/422 (31%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	224/402 (56%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	131/422 (31%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	224/402 (56%)
		Lig_chan	610..906	CDD:459656	164/299 (55%)