Protein Alignment GRIA3 and GluRIIB

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 951
• Identity: 258/951 - (27%)
• Similarity: 421/951 - (44%)
• Gaps: 147/951 - (15%)

Human    17 FLVLGLLGHSHGGFPNT--ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLD 79
            ||||..|..:.|...:|  |.||.:|....::...||..|::    ..|.......|:....::.
  Fly     6 FLVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALE----EVNAINPALKLDAIKRYVT 66

Human    80 SSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFC---GALHTSF---VTPSFPTDADVQFV 138
            ..:|..:.:..|.....||.||||...:.:.:.:...|   |..|..|   ...|.....:.|..
  Fly    67 VDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLT 131

Human   139 IQMRPA---LKGAILSLLGH--YKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKD 198
            :.:.|.   |..|...:|..  :.|:.|...|:.......||.|:.      |:...::  .||
  Fly   132 VNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILA------WKQLHKA--GIK- 187

Human   199 VQEFRR------IIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGY-------HYMLANL 250
            :|||.|      :.:.::..:||..|:||.    :.||..|:   ..|.||       |..|.||
  Fly   188 MQEFERGDDYRILWKRINNAREKFVLLDCP----SDILVDVI---NASIGYNMTGSFNHLFLTNL 245

Human   251 GFTDILLERVMHGGANITGF------------QIVNNENPMVQQFIQRWVRLDEREFPEAKNAPL 303
               |..|       :.|.||            :|.....|.|...|..:....:..|.
  Fly   246 ---DTHL-------SGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFS------- 293

Human   304 KYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVP---WSQGIDIERAL-----KM 360
            ...|.|.:|:|::...|.       :::|:|  .|..:.|.:..   |..|..:...:     ||
  Fly   294 SLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKM 349

Human   361 VQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENR-- 423
            |:....|..:|.:..|:|.::.::||...:  .|....||:..:.|.|...:.::..|..:.|
  Fly   350 VKPPFKTQRLQINADGQREDFNLEVYNPII--DRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQ 412

Human   424 ----------TIVVTTILESPYVMYKKNHE--QLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVG 476
                      ...|.|.:..||..:::..|  ..|||||:|||.|||.|.:|:..:..:....|.
  Fly   413 NKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVR 477

Human   477 DGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 541
            |.|||:.|..|..|:|::.:|:...|.|.:..||||..|..|:||:.|||.|||||:..|....|
  Fly   478 DNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPK 542

Human   542 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH--LEDNNEEPRDPQSPPDPPNEFG 604
            ..:::||:|...|:|:.::.|.:..:..|....|...|||.  :|:.|.|       .:..|.:.
  Fly   543 ADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE-------MERQNIWH 600

Human   605 IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAE 669
            :.|:||..||:.:.||||:.||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..
  Fly   601 LSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLH 665

Human   670 DLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAF 734
            ||..|.::.:||:..|:|..:|..|........|:.|.|.:|..|||...:||.||:.|||.:||
  Fly   666 DLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAF 730

Human   735 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWW 799
            |:|:|..:|..||. |:..::|.:...|.||:|.|..:..|:.:::.:|:|:|:|.|.||:|||:
  Fly   731 LMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWF 794

Human   800 -YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNT 863
             .::..|.|......|  ....:.:|.|:|.:|:.|:.:.:::.:.||.:..:..|.:.|:
  Fly   795 NSNESTCDSNVPTIDD--GQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI---- 853

Human   864 QNFKPAPATNTQNY------------ATYRE-------GYN 885
               .|..|...:.|            .|||:       ||:
  Fly   854 ---PPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYS 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	88/417 (21%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	140/399 (35%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	85/408 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/380 (37%)