Protein Alignment GRIA3 and Ir25a

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 976
• Identity: 257/976 - (26%)
• Similarity: 427/976 - (43%)
• Gaps: 213/976 - (21%)

Human    33 TISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFS--VTNAFCSQFS 95
            |.:|..||:.....|.:|....|.|....:|..   :.|:..:|.::::.|.:  :..|.|::::
  Fly    33 TQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR---YGLSVQLDSIEANKSDAKVLLEAICNKYA 94

Human    96 RGV------YAIFGFYDQ-MSMNTLTSFCGALHTSFVTPSFPTDADV-----------QFVIQMR 142
            ..:      :.|...... ::..|:.||..||....::.|:....|:           ::::|:.
  Fly    95 TSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVM 159

Human   143 P---ALKGAILSLLGHYKWEKFVYLYD-----TERGFSILQAIMEAAVQNNWQVTARSVGNIKDV 199
            |   .:..||.|::.|........|||     ..:..|:||.|     |....:||
  Fly   160 PPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNI-----QTRHVITA--------- 210

Human   200 QEFRRIIEEMDRRQEKRYLIDCEVERI-NTILEQVVILGKHSRGYHYMLANLGFTDILLERV--M 261
                 |.::..|.:|:      ::|:: |..:....|||           .|....::||.|  .
  Fly   211 -----IAKDGKREREE------QIEKLRNLDINNFFILG-----------TLQSIRMVLESVKPA 253

Human   262 HGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNA------PLKYTSALTHDAIL----- 315
            :...|.....|..||..:..|               ..||      |:.||.......:|
  Fly   254 YFERNFAWHAITQNEGEISSQ---------------RDNATIMFMKPMAYTQYRDRLGLLRTTYN 303

Human   316 -----VIAEAFRYLRRQRVDVSRRG--SAGDCLANPAVP----------WSQGIDIERALKM--- 360
                 .::.||.:      |::.|.  :..:.|.:.|.|          :..|...:|.|.:
  Fly   304 LNEEPQLSSAFYF------DLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDY 362

Human   361 -VQVQGMTGNIQFDTYGRRT---------NYTIDVYEMKVSG-----SRKAGYW--NEYERFVPF 408
             .::...|....||...:.|         .:.:|:..:::.|     |:..|.|  ......:..
  Fly   363 FTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVK 427

Human   409 SDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLS 473
            .::|:.|.:|.:..|   :.|::::|::|  ::....:|   |:|||:||..|||..|...|.:.
  Fly   428 DEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAPKG---YKGYCIDLINEIAAIVHFDYTIQ 484

Human   474 IVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKP 537
            .|.|||:|..| |...|||:|.:|:..:|||.:..:::...||.||||:.|:..| ||:||:::|
  Fly   485 EVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP 548

Human   538 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNE 602
             .|...:|.||..|...:|:||:.||...|.::::..|:|||.:  ::|.|:.:|.:.    ..|
  Fly   549 -SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY--QNNREKYKDDEE----KRE 606

Human   603 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 667
            |.:...|||.:.:...||...:|::||||:|...||.|..|||:||||||||||||.|:.:|:||
  Fly   607 FNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVES 671

Human   668 AEDLAKQTEIAYGTLDSGSTKEFF--------------------------RRSKIAV-------- 698
            .:|||||.:|.|..|:..|...:|                          .|||:||
  Fly   672 LDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDK 736

Human   699 YEKMWSYMKSAEPSVFTKTTADGVARVRKSKGK--FAFLLESTMNEYIEQRKPCDTMKVGGNLDS 761
            |.|||..|:.|:   ...|..:.|||||.|...  ||||.::|...|: |...||...||.....
  Fly   737 YTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSR 797

Human   762 KGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSN 823
            |.|.:|..:||.|::..|.|:|.|..:..|:|||.|||.:.   .:|..    .:|::..:|:.|
  Fly   798 KPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDK----PEDQSDGISIQN 858

Human   824 VAGVFYILVGGLGLAMMVALIEF-CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVY 887
            :.|||.::..|:|:|.:..:.|: .|:.|         ||.:....|.|...::.|....|..|.
  Fly   859 IGGVFIVIFVGIGMACITLVFEYWWYRYR---------KNPRIIDVAEANAERSNAADHPGKLVD 914

Human   888 G 888
            |
  Fly   915 G 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	79/452 (17%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	153/422 (36%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	78/440 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	152/417 (36%)