Protein Alignment GRIA3 and GluRIIC

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 867
• Identity: 260/867 - (29%)
• Similarity: 412/867 - (47%)
• Gaps: 65/867 - (7%)

Human    34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHL-DSSNSFSVTNAFCSQFSRG 97
            |:||..|..:.::....|...|...|..:  :|:.......:..| ....|.::....|.....|
  Fly    25 INIGAFFYDDELELEKEFMTVVNAINGPE--SEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNG 87

Human    98 VYAIFGFYDQMSMNTLTSFC---GALHTSFVTPSFPTDADV---QFVIQMRPA---LKGAILSLL 153
            |.||||...:.:.:.:...|   |..|..|........|:.   |..:.:.||   |..|...::
  Fly    88 VAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIV 152

Human   154 GHYKWEKFVYLYDTE--RGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKR 216
            .::.|.||..:||.:  |..:.||.:::....:|..|..|...  || .:||.:.:.:  |.|:|
  Fly   153 QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFH--KD-DDFRVMWKSI--RGERR 212

Human   217 YLIDCEVERINTILEQVVILGKHSRGYHYMLANL-GFTDILLERVMHG---GANITGFQIVNNEN 277
            .::|||...:..:|......|...:..|..|.|| .:||.|.|.....   ..|||..:::.|.:
  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPD 277

Human   278 PMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR---YLRRQRVDVSRRGSAGD 339
            |........:|...:....|:.:.|......|.|||:.:.|:::|   :....|:.|.|  ...|
  Fly   278 PPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCD 340

Human   340 CLANPAVPWSQGIDIERALK----MVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWN 400
            ..|:....|:.|..:.|.:|    :......|..:|||..|:|..:.|:||: .:.|...| .|:
  Fly   341 FAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD-PLDGIGIA-IWD 403

Human   401 EYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLE--GNERYEGYCVDLAYEIA 463
            ...:..     |::.|..:.:.....|.|.:..||..|.:...:|.  ||..|:||.|||...||
  Fly   404 PRGQIT-----QLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIA 463

Human   464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 528
            :||..:|....|.|.:||..|.|||.|||::||::...|.:.:..||||..|:..:||:.|||.|
  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528

Human   529 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHLEDNNEEP 590
            |:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|    .|..|
  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDW----ENPHP 586

Human   591 --RDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 653
              |||:.   ..|::.|.|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||
  Fly   587 CNRDPEV---LENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLA 648

Human   654 AFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT 718
            ||||..:|...|.:.:||:.|.::.:||:..|||......|...||...::.|.:.:||.:||..
  Fly   649 AFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDN 713

Human   719 ADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVL 783
            .:||.||||::|.:.||:|:|..|| .:.:.||...||.....|.|.:|.|.|:..|:.:::|:|
  Fly   714 LEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAIL 777

Human   784 KLNEQGLLDKLKNKWWYD-KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFC 847
            ||:|:|.|..||.|||.: ...|..  ....|.|..::...:.|:||.|..|:.:|.::.:.||.
  Fly   778 KLSERGELYDLKQKWWKNPNASCFE--EPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFL 840

Human   848 YKSRAESKRMKLTKNTQNFKPA 869
            ...:..:...:||     ||.|
  Fly   841 VYVQQVALEERLT-----FKDA 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	92/396 (23%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	149/390 (38%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	92/393 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	148/381 (39%)
		Lig_chan	554..827	CDD:459656	106/285 (37%)