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Protein Alignment GRIA3 and Ir8a

DIOPT Version :9

Sequence 1:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	853	Identity:	211/853 - (24%)
Similarity:	364/853 - (42%)	Gaps:	199/853 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   141 MRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA--AVQNNWQVTARSVGNIKDVQEFR 203
            |||     .|.:.|.:..:|        |..::....|.|  ||:...|:.   ||     ..||
  Fly   114 MRP-----FLDMFGDFMRQK--------RANNVAMVFMNARDAVEAMQQML---VG-----YPFR 157

Human   204 RIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANIT 268
            .:|.:..:....::.:    |||.::        :.:..|..:.|.....:.:.|:|.....
  Fly   158 TLIMDASQTDPGQHFL----ERIRSL--------RPAPTYIALFARAAAMNGIFEKVQKADL--- 207

Human   269 GFQIVNNENPMVQQFIQRWVRLDERE--FPEAKNAPLKYTSALTHDAI--------LVIAEAFRY 323
             ||     .|:...|    |.||.|:  |...:.|.|.....|...||        |.....|..
  Fly   208 -FQ-----RPLEWHF----VFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTM 262

Human   324 LRRQRVDVSR------RGSAG-------DCLANPA------------------VPWSQGIDIERA 357
            .|...::|.|      :.|.|       ||.|..:                  |.||..:.....
  Fly   263 QRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPP 327

Human   358 LKMVQ------VQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYW-NEYE------RFVPFS 409
            |..:|      |.|:|             :.:::         .|||: :|:|      .:....
  Fly   328 LPHIQDQFQSPVPGLT-------------FAVNI---------SAGYYSSEHEAKTDLAAWSSVG 370

Human   410 DQQISNDSASSENRTIVVTTILESPYVMYKKNHE-------QLEGNERYEGYCVDLAYEIAKHVR 467
            :.::.|::.|...|...:.|....|: .|.:..|       ...|...:||||:|....:::.:.
  Fly   371 EMRLLNETISPARRFFRIGTAESIPW-SYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLN 434

Human   468 IKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFM-SLGIS 531
            .::::.....|..|..: |...|:|:||:||.|..|.|:|.|.:...|||||||..|:. ..|||
  Fly   435 FEFEIVAPEVGHMGELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGIS 498

Human   532 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSP 596
            |.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::::.:.::|||.   ..||.     |:.
  Fly   499 IAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYS---SRNNR-----QAY 554

Human   597 PDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 661
            |....||.:..|.||:|.:|..||...:|:::|||::...:|.|.:::::::|||||||||||||
  Fly   555 PYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERM 619

Human   662 VSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA---VYE----------------KMWSY-- 705
            .:|::|.|.||:|:.|.|..:....|.::|...|.|   :|.                ::|.|
  Fly   620 QTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPI 684

Human   706 ----------MKSAEPSVFTKTTADGVARV-RKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNL 759
                      :.|::|....|   :|.|.| ......:||:.:|...:| |..:.|:..:||...
  Fly   685 KEQYGHILLAINSSQPVADAK---EGFANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVF 745

Human   760 DSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKG--ECGSGGGDSKDKTSALSLS 822
            ..:.|.||..:||.|.:.::.|:|:|.:....::||.|:|....  .|..    |:|: ..::|.
  Fly   746 AEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPL----SEDQ-EGITLE 805

Human   823 NVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTK---------NTQNFKPAPATNTQNYA 878
            ::.|||...:.||.||||...:|..|..:.:: .:::|:         :..|...||.|.|   :
  Fly   806 SLGGVFIATLFGLVLAMMTLGMEVLYYKKKQN-ALEITQVRPVNDSSGSGGNSSTAPPTAT---S 866

Human   879 TYREGYNV 886
            |.::.:::
  Fly   867 TTKQAWHI 874

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.