Protein Alignment GRIA3 and GluRIIE

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Alignment Length: 876
• Identity: 293/876 - (33%)
• Similarity: 459/876 - (52%)
• Gaps: 91/876 - (10%)

Human    17 FLVLGLLGHSH-----------GGFPN-----TISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTT 65
            |::|..|...|           ||:.|     ::.||.|..:||.|.:..|..|:.:  .||...
  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDV--ANQEVG 68

Human    66 EKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 130
            .....|...|::.|:..|:   ...|.....|:..:||...:.:...|.|.|.|:....:. |:.
  Fly    69 TSLTSLKEEVNYGDAYQSY---GKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYM 129

Human   131 TDADVQFVIQMRPA-LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA---- 190
            ::....|.:...|| |..|:.||:..:.|.:|::||::....:||..:.....::...:|.
  Fly   130 SENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYD 194

Human   191 -RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTD 254
             :..||.|.|  .||:.:.:|    .|.::....|.:...|.|...:|..:..|.|::.||.|..
  Fly   195 MQLNGNYKQV--LRRVRKSVD----NRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHS 253

Human   255 ILLERVMHGGANITGFQIVNNENPMVQQFIQR-WVRLDEREFPEAKNAPLKYTSALTHDAILVIA 318
            ..||...:..|||||.::.:.|...|::.:.: ....|:.||... :.|:....|||:||:.:.|
  Fly   254 FDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNG-SCPITVEMALTYDAVQLFA 317

Human   319 EAFRYLR--------RQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTY 375
            :..:.|.        .||.:..|  ..|....|          ..|.|::.. :.:||.|.|:..
  Fly   318 QTLKNLPFKPMPQNCSQRTESVR--DDGSSFKN----------YMRTLRLTD-RLLTGPIYFEGN 369

Human   376 GRRTNYTIDVYEMKVSGSRKAGYWNE---Y--ERFVPFSDQQISNDSASSENRTIVVTTILESPY 435
            .|: .|.:||.|::.||..|.|.|:|   |  :|..|.:.|..|.|::.:....|::.::...||
  Fly   370 VRK-GYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPY 433

Human   436 VMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGK-YGARDPETKIWNGMVGELVY 499
            ....:.::|||||.:||||.|||..|:|.  ::.:..:.|..|. ||:.:..|....||:.|::.
  Fly   434 AQLVETYKQLEGNSQYEGYGVDLIKELAD--KLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMT 496

Human   500 GRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 564
            ||||:|:..||||..||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::
  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFL 561

Human   565 GVSVVLFLVSRFSPYEWHLEDNN----EEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISP 625
            |||:..|::.|.||.||   ||.    |||.:.:      |:|.:.||:||:.||.:|||.:|.|
  Fly   562 GVSLSFFILGRLSPSEW---DNPYPCIEEPEELE------NQFTLGNSIWFTTGALLQQGSEIGP 617

Human   626 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLDSGSTKE 689
            ::||.|.|...|||||||::||||||||||||:|:..|.|.|.:|||...: :.||...:|||:.
  Fly   618 KALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRN 682

Human   690 FFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMK 754
            ||..|....|:||..:| |..|...|:...:||.|| |:...:|||:|||..||..:|: |:..|
  Fly   683 FFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKK 744

Human   755 VGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG----GGDSKDK 815
            :|..||.||||:|..|....|...|.|:|:|.|||:|:|:|||||   .|.|:|    ..|:.|.
  Fly   745 IGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW---NEVGTGICATKEDAPDA 806

Human   816 TSALSLSNVAGVFYILVGGLGLAMMVALIEF 846
            | .|.::|:.|||::|:.|...|::..:|.:
  Fly   807 T-PLDMNNLEGVFFVLLVGSCCALLYGIISW 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	99/393 (25%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	169/388 (44%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	97/388 (25%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	169/387 (44%)
		Lig_chan	551..824	CDD:459656	127/288 (44%)