Protein Alignment GRIA3 and Nmdar2

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Alignment Length: 900
• Identity: 207/900 - (23%)
• Similarity: 349/900 - (38%)
• Gaps: 222/900 - (24%)

Human    72 NYHVDHLDSSNS-FSVTNAFCSQFSR-GVYAI--------FGFYDQMSMNTLTSFCGALHTSFVT 126
            |.|.|.:..:.| .::.:..|.:|.| .|.||        || :...|........|.|....:
  Fly   148 NIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQLAGYLGIPVI- 210

Human   127 PSFPTD--------ADVQFVIQMRPALK---GAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA 180
             |:..|        :.....:|:.|:::   .|:||:|..|||.:          ||:
  Fly   211 -SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQ----------FSV------- 257

Human   181 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILE------QVVILGKH 239
                   ||::..|:...||..|..:.||....:...|....|.|.:.::|      :|::|
  Fly   258 -------VTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLMELVNSEARVMLL--- 312

Human   240 SRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLK 304
                 |.......|.:.....|    .:||               :.:|.:..:...|.|:|..:
  Fly   313 -----YATQTEAITILRAAEEM----KLTG---------------ENYVWVVSQSVIEKKDAHSQ 353

Human   305 Y------------TSALTHD---AILVIA---EAF--------RYLRRQRVDVSRRGSAGDCLAN 343
            :            ::||.::   ||.:.:   ||:        |.|..|.:.....|..
  Fly   354 FPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG------ 412

Human   344 PAVPWSQGIDIERALKMVQVQGMTG--NIQFDTYGRRTNYTIDVYEMKVSGSRK------AGYWN 400
               .|..|....:.|:.|.::|...  ||:|...|...:..:.:..::.|.:.|      .|.|.
  Fly   413 ---RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474

Human   401 EYE------RFVPFSDQQISNDSASSENRTIVVTTILESPYV--------------------MYK 439
            .:|      |.:.:.....:......|...:.:|.:.|:||:                    ...
  Fly   475 SWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVA 539

Human   440 KNHE--------QLEGNERY----EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNG 492
            .:||        |...||.:    .|:|:||..:.|:.:...|:|..|.|||:|..  |...|||
  Fly   540 ADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL--ENGKWNG 602

Human   493 MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYE 554
            ::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|   ||:|....
  Fly   603 LIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTA 663

Human   555 IWMCI-VFAYIGVSVVLFLVSRFSP--YEW--HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLG 614
            .||.: :.|....:.::||....||  |:.  :|::.|.          .|..|.:|.:.|....
  Fly   664 SWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNV----------TPYRFSLFRTYWLVWA 718

Human   615 AFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPIE 666
            ...|....: |||..:.|.:..||..|.::.::.||||||||            |...|:|.|
  Fly   719 VLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP-- 781

Human   667 SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT-ADGVARVRKSKG 730
                .:.:....:||:....|.....:    .:..|.:||:.     :.||: |||||.|  ..|
  Fly   782 ----FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNG 831

Human   731 KF-AFLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDK 793
            .. :|:.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:....|.|::
  Fly   832 NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLER 896

Human   794 LKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
            |:..|.  .|.|..|..:.| .:..|:|......|.:|:.|:.||.::.|:|..|
  Fly   897 LRRYWM--TGTCRPGKQEHK-SSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	76/403 (19%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	117/438 (27%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	75/399 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	118/440 (27%)