Protein Alignment GRIA3 and Ir41a

DIOPT Version :10

• Sequence 1: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 101/543 - (18%)
• Similarity: 186/543 - (34%)
• Gaps: 122/543 - (22%)

Human   369 NIQFDTYGRRTNYTIDVYEMKVSGSRKA----------GYWNEYERFVPFSDQQISNDSASSENR 423
            ||.|......:..:.|:...|..| |||          .|....:|| .|.....::...:.:.|
  Fly   149 NILFVVRDHSSASSFDIKTNKFVG-RKAENPSQMILVDRYLASEQRF-QFGKSLFADKLNNLQGR 211

Human   424 TIVVTTILESPYVMYKKNHEQ------LEGNERYEGYCVD-----LAYEIAKHVRIKYKLSIVGD 477
            .:::......||.:.|.|...      :.|...::...:|     :.....:......::.....
  Fly   212 EVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAA 276

Human   478 GKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKP 542
            ..:|...|... .:|.:|.|:..:|||.:..:.........:|.|...:..||:.::..|.:...
  Fly   277 NDWGKVYPNMS-GDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTS 340

Human   543 GVFSFLDPLAYEIW------MC-----IVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSP 596
            .... |:|....:|      :|     :|.||.. ...|:::..:....|..
  Fly   341 WYLP-LEPFKETLWAAILLCLCAEATGLVLAYKS-EQALYVLPGYREGWWTC------------- 390

Human   597 PDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 661
                ..||:..:  |.|  |:.|..:....||:.|::....:...|||.|.|...||:.||:..|
  Fly   391 ----TSFGVCTT--FKL--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM 447

Human   662 VSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW-SYMKSAEPSV-------FTKTT 718
                :.|.|..              |:..|.|.:.|...:.| |.:::::.::       |...:
  Fly   448 ----DEAADTV--------------TRLRFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYS 494

Human   719 ADGVARVRKSKG-KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG--------------YGVA- 767
            .|.:.|:.:.:. :..|.:|         |.|.....:|..|..:.              |.||
  Fly   495 DDELLRLAQDQHMRIGFTVE---------RLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAF 550

Human   768 TPKGSALRNAVNLAVLKLNEQG---------LLDKLKNKWWYDKGECGSGGGDSKD-KTSALSLS 822
            .|:...|.:.:|..:...:..|         :.|.|..|......|..:|   :|| ....|.:|
  Fly   551 VPRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTG---TKDIGPVPLGMS 612

Human   823 NVAGVFYILVGGLGLAMMVALIE 845
            |.||...:.:.|..:|.:..|:|
  Fly   613 NFAGFIIVWILGSAIATLTFLLE 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	12/49 (24%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	75/437 (17%)
Ir41a	NP_995744.4	None