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Protein Alignment GRIA2 and Ir75b

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	120/512 - (23%)
Similarity:	196/512 - (38%)	Gaps:	102/512 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   364 QNGKRINYTIN--IMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPY 426
            |.|..:|.|.:  |...||| .|...|.||    :.|.:.|......:||..:...|.|.|  |.
  Fly   145 QLGGELNITADREIFCNKTN-CRVERYLSE----LYTRSALQHRKSFTGLTMRATAVVTAL--PL 202

Human   427 -VMMKKNHEMLEGNERYE-------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNG 483
             |.:|:..:.:....|.:       ||...........|.|||   |..|     |.:|.....|
  Fly   203 NVSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKY---IFRD-----RWSDGNATGG 259

Human   484 MVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKPGVFS--FLDPLA 543
            |:|:|:..|||:||||...:..|..   |.:|.....:   ..|.:.|:....|:.:  ||.|.:
  Fly   260 MIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFS 321

Human   544 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQ 608
            ..:|:......:....:|          |.|...|..::.:.|       :..|...|.||...|
  Fly   322 GGVWLTFALLLLLAGCLL----------WVTFILERRKQWKPS-------LLTSCLLSFGAGCIQ 369

Human   609 GCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTEIAYGTLD 672
            |..::|||:.||:.     ||.|::.|....|....:.|.::: .||:|  ::....::|...||
  Fly   370 GAWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLD 427

Human   673 SG-----------------STKEFFRRSKIAVF---DKMWTYMRSAEPSVFVRTTAEGVARVRKS 717
            .|                 ..::.:|:..:...   ||:|.            .|..||..||..
  Fly   428 VGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWI------------PTEAGVLSVRDQ 480

Human   718 KGKYAYLL-ESTMNEYIEQ----RKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQ 777
            :| :.|:. .:|..|::.:    .:.|:..::... |:........|.|.....:.|:.|::.|.
  Fly   481 EG-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAELIKLSELRMLET 543

Human   778 GVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834
            ||..|.:..|...|..|     .....|.|:.|...|.:|.||:|.:.|.|.:..:|
  Fly   544 GVHFKHERSWMETKLHC-----YQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLE 595

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.