DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir7f

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_001138177.1 Gene:Ir7f / 7354418 FlyBaseID:FBgn0259188 Length:621 Species:Drosophila melanogaster


Alignment Length:443 Identity:72/443 - (16%)
Similarity:157/443 - (35%) Gaps:86/443 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   416 VVVTTILESPYVMM----KKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL---TIVGDGKYGA 473
            :.|.|..:.|:|.:    |.|      ..|..|:.:.|...:|:...|..:|   .::....|..
  Fly   229 LTVLTWHQPPFVELVWDPKHN------RSRGSGFEIQLVEHLARRMNFSLELVNIALLRPNAYRL 287

Human   474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 538
            .:..::   |.:.:|:....:|::.....|..|.:::.....:.|..: :.:.:.::.:.|..:.
  Fly   288 AEGSSE---GPIEKLLQRNVNISMGYFRKTARRNQLLTTPMSYYSANL-VAVLQLERYRIGSLAL 348

Human   539 L-DPLAYEIWMCIVFA---YIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLW 599
            | .|....:||.::.|   ::|:               |......|.|....      |....:.
  Fly   349 LVFPFELSVWMLLLLALLIHLGI---------------HLPSARRGNEEDGG------GGLQVVA 392

Human   600 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQT 664
            ..|||.:.:    .|||...|.:...|.:.::.:..||.:.|...:.::...:|..|.:.|  ..
  Fly   393 LLLGAALAR----LPRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQL--LA 451

Human   665 EIAYGTLDSGSTKEFFRRSKIA-----------VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSK 718
            |...|...:.:.:......::|           .||  |..:     :|..|.....:..|....
  Fly   452 EGFQGICTANTQRLLLEMPQLARDPDSIQSVDTPFD--WDVL-----NVLTRNRNRKIFAVANQD 509

Human   719 GKYAYLLEST-MNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDK 782
            ...::|..|. .|.:...::|         ::.:..|:..||.|.|...::..:.:|...|.:..
  Fly   510 VTLSFLHSSAHPNAFHVVKQP---------VNVEYAGMYMPKHSFLYEKMDDDIRRLDASGFIHA 565

Human   783 LKNKWWYDKGECGAKDSGSKEKTSA--LSLSNVAGVFYILVGGLGLAMLVALI 833
                 |................||.  ::.:.::|::.::.   ||.:|..|:
  Fly   566 -----WRRASFASVHRKEQVHMTSRRYINHAKLSGIYMVMA---GLYLLAGLL 610

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612
PBP2_iGluR_AMPA 413..794 CDD:270433 65/400 (16%)
Glutamate binding 499..501 0/1 (0%)