DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir7e

DIOPT Version :10

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_001138176.1 Gene:Ir7e / 7354417 FlyBaseID:FBgn0259189 Length:608 Species:Drosophila melanogaster


Alignment Length:439 Identity:78/439 - (17%)
Similarity:162/439 - (36%) Gaps:94/439 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   425 PYVMMKKN-HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGEL 488
            |::.:.:: .|:|..|..|||..:...||       |...||      ..|.....:.:..:..|
  Fly   221 PFLTLDEDQEEVLRVNGGYEGRLLLALAE-------KMNFTI------AVRKVHVNMRDEALEML 272

Human   489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLG--ISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 551
            ...:.|:.:..:..|:.|..|...|..:....  ..::....:.|...:..:  |...:|||.|:
  Fly   273 RRDEVDLTLGGIRQTVARGMVATSSHNYHQTREVFGVLASSYELSSFDILFY--PYRLQIWMGIL 335

Human   552 FAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLG-AFMQQGCDISPR 615
            ......:::..:|.|..            ||...|.          .|.:|. .|:.......||
  Fly   336 GVVALSALIQLIVGRML------------RERMGSR----------FWLNLELVFVGMPLLECPR 378

Human   616 SLSGRIVGGVWWFFTLIIISSYTANLAAFL----------TVERMV--------SPI--ESAEDL 660
            |.:.|:...:...:||||.:.|...|...:          |:|.:|        :||  |..:::
  Fly   379 SHTARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEI 443

Human   661 SKQTEIAYGTLDSGSTKE--FFRRSKIAVFDKMWTYMRSAEPSVFV---RTTAEGVARVRKSKGK 720
            .....:.:..|::.|..:  :|..:.    .::..::.::...:|:   |.:|:.|.: |..:|.
  Fly   444 PSVQHMRFRLLEANSELDPLYFLEAN----HQLRQHVTASALDIFIHFNRLSADKVHQ-RGEQGS 503

Human   721 YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKN 785
            .|: .|....:.|..:.   ||.:.             |.|.|...:|..::.:...|:| .:.:
  Fly   504 GAH-FEIVPEDIISMQL---TMYLA-------------KHSFLIDQLNEEIMWMRSVGLL-SVWS 550

Human   786 KWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834
            :|     |.......:::....|....:..:|.:::.||.:.:||.::|
  Fly   551 RW-----ELSESYLRNEQSFQVLGTMELYAIFLMVLVGLIVGLLVFILE 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612
PBP2_iGluR_AMPA 413..794 CDD:270433 70/397 (18%)
Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491 867..877
Ir7eNP_001138176.1 Periplasmic_Binding_Protein_Type_2 218..>313 CDD:473866 19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

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