back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIA2 and Ir7d

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001138175.1	Gene:	Ir7d / 7354416	FlyBaseID:	FBgn0259190	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	86/466 - (18%)
Similarity:	157/466 - (33%)	Gaps:	136/466 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   415 TVVVTTILESPYVMMK-KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGD--GKYGARDA 476
            :|:|..|  .||:.:. |:.:.::|.:..:|..:.:   :|:...|..|| |..:  |..|....
  Fly   213 SVIVWDI--PPYMRINWKSSDPMDGLDGLDGLLLRI---VARKMNFTLKL-IPNEPNGLIGGSSF 271

Human   477 DTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 541
            ....:.|....|...:|:|.|.....|..|...::.:.|:..:...|::    :::.|
  Fly   272 MNGTFTGAYKMLRERRANITIGCAACTPERSTFLEATSPYSQMSYIIVL----QARGG------- 325

Human   542 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFM 606
              |.|:..::|.:  ......|:|......|                     |..|.|
  Fly   326 --YSIYEVMLFPF--EKYTWLLLSTILGLHW---------------------IVGSRW------- 358

Human   607 QQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTL 671
                    |..|..:.|.:.|.|  :|.:||.|::..|:    ..||::.:.          .||
  Fly   359 --------RMPSPILAGWMLWIF--VIRASYEASVFNFI----QNSPVKPSP----------RTL 399

Human   672 DSGSTKEF--------FRRS-KIAVFDKMWTYMRSAEP-SVFVRT---------------TAEGV 711
            |...:..|        :|.: ||..|... |.:.:.:| .||...               .|:.:
  Fly   400 DQALSGGFRFITDHASYRMTLKIPSFQGK-TLISAGQPVDVFDALLKAPWKTGAFTSRAFLADHL 463

Human   712 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSE 776
            .|.||.:.:...|.|..::..:     |               :..|.||.....:|..:..:..
  Fly   464 VRHRKHRNQLVILAEKIVDNML-----C---------------MYFPHGSYFAWEINKLLFNMRS 508

Human   777 QGVL---------DKLKNKWWYDKGECGAKDSGSKEKTS---ALSLSNVAGVFYILVGGLGLAML 829
            .|:.         |.|...  .|....|.:...|.|..:   |.|:|.|......|:|.|.::::
  Fly   509 FGIFQHHSQILAWDNLPTT--TDTDTPGKRIHSSTESVATGFAESMSFVVAALNCLMGALCISIV 571

Human   830 VALIEFCYKSR 840
            |..:|...:.|
  Fly   572 VFGLELLSRRR 582

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.