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Protein Alignment GRIA2 and Ir94d

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001138099.1	Gene:	Ir94d / 7354412	FlyBaseID:	FBgn0259193	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	135/739 - (18%)
Similarity:	233/739 - (31%)	Gaps:	253/739 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   189 DEMYRSLFQDL--ELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQ 251
            |..|.||...|  |||.|                            |..::.|...|..|:|
  Fly    19 DSFYHSLIHHLNRELKIE----------------------------YVLLLGNFDTTWLDIL--- 52

Human   252 FGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRK 316
             ....||..||.::..       |.:|.||.   |..:..||.:.:....|.::::....|.|..
  Fly    53 -WQLPVSVLQIKEHSR-------ETYSLLEN---PSHNVLTIAFVNDSPEDILEILYRNLRMLNT 106

Human   317 QRIEISRRGNAGDCLANPAVPWGQGVEIER--ALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379
            |.:.:..|.:.  ...|..:.|....::.:  |:.|..:|.|            |.|:.|...:.
  Fly   107 QPVLLVIRKST--IRVNSLLEWCWHHQLLKVVAIAQDFMESL------------IVYSYNPFPVL 157

Human   380 TNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILE--------------SPYVMMK 430
            ....|:                         |:|.||:....||              ||.:::.
  Fly   158 QFIERR-------------------------LDNSTVIFEKRLENLHGYEVPIALGGSSPRLIVY 197

Human   431 KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG------ARDADTKIWNGMVGELV 489
            ::   |||...:.|    ......|....:|...:|....:.      |||....:.||.| ::.
  Fly   198 RD---LEGKLIFSG----PVGNFMKSFEQRYNCRLVQPYPFDESAISPARDLIASVQNGSV-QIA 254

Human   490 YGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG-----VFSFLDPLAYEIWMC 549
            .|    ||.|      :.....:|.|...:...:|:..|::....     |||   |:|:.|
  Fly   255 LG----AIYP------QVPYTGYSYPIELMSWCLMMPVPEEVPHSQLYSMVFS---PMAFGI--- 303

Human   550 IVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-- 612
            .:.|.:.:|:.|.:..|...|.               .|.:|:.:.:|.  ..|...|...::
  Fly   304 TIVAMVLISLTLSMALRLHGYR---------------VSFSEYFLHDSC--LRGVLSQSFYEVLR 351

Human   613 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTK 677
            :|..:....:  |.....|:|.|.|.:..:.|:|.......:.|.|.:
  Fly   352 APALIKAMYL--VICLLGLLITSWYNSYFSTFVTSAPRFPQLTSYESI----------------- 397

Human   678 EFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYA--YLLESTMNEYIEQRKPCD 740
               |.|.|    |:..:....|..:|.....|          ||:  :.|:....|::..|...|
  Fly   398 ---RHSNI----KIVIWKPEYEMLLFFSENME----------KYSSIFQLQEDYKEFLHLRDSFD 445

Human   741 TMKVGGNLDSKGYGIATP--------------------------------------KGSSLRTPV 767
            |.          ||...|                                      |.|..:.|.
  Fly   446 TR----------YGYMMPMEKWSLMKEQQRVFSSPLFSLQDDLCVFHTVPIVFPMVKNSIFKEPF 500

Human   768 NLAVLKLSEQGVLDKLKNKWWYD--------KGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 824
            :..:|.::..|:|.:     |.|        .|:.|.:|.|..::..|:.:.::..::..:...|
  Fly   501 DRLILDVTATGLLSR-----WRDMSFTEMIKAGQLGLEDRGHPKEFRAMKVGDLIQIWRFVGWML 560

Human   825 GLAMLVALIE-FCYKSRAEAKRMK 847
            |||.:|.|:| .|:......:.||
  Fly   561 GLATIVFLLELICFWRHKMWQNMK 584

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.