DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and GluRIB

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster


Alignment Length:995 Identity:410/995 - (41%)
Similarity:559/995 - (56%) Gaps:194/995 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    14 VLW---------GLIFGVS-----SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTP 60
            :||         |...|||     :..|.:|.:|.:|.|:..|||:..|    :..|:..|.|..
  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQA 79

Human    61 HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTD 119
            ::|.:..|::|.::...|:|||||||::.|.....|.:|:.|:..|..:.|:||.|      |:.
  Fly    80 YVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSS 144

Human   120 GTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDS--AAEKKWQVTAINVGN 182
            |...|.:.||||...|::..|::|.|.|..|||||..||..||.:...  ...:.:||..:.  .
  Fly   145 GFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK--R 207

Human   183 INNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVI---TIGKHVKGYHYIIANLGFTD 244
            |:|......:....:.:...:.:.::|||..:....|:.|.:   .:|:  :.|||:::.|...|
  Fly   208 ISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDD 270

Human   245 ---GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQV 306
               .::  |:||..|::||:|||.:..||.:|.:.|..|:.:...||...:|...:||.||||.|
  Fly   271 RWESEI--IEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFV 333

Human   307 MTEAFRN-LRKQ----RIEISRR---------------------------GNAG----------- 328
            :.|||.. |||:    |..:.||                           ||.|           
  Fly   334 LVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSG 398

Human   329 ----------DCLANPAV----PWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379
                      ||  |.|.    .|..|.:|.|.|::|::|||:|:|||:.:|:|:|||::::|:.
  Fly   399 GSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT 461

Human   380 TNGPR-KIGYWSEVDKMVVTLTELPSGNDTSGLE-----------------NKTVVVTTILESPY 426
            .|... |:..|                ||.:||:                 |:|.:|||:||.||
  Fly   462 VNSAMVKVAEW----------------NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPY 510

Human   427 VMMKK--NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGEL 488
            :|:|:  ..|.|.||.|:||||.|||..:||..|..|:|.:|.||.||:..:... .|:||||||
  Fly   511 IMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGEL 575

Human   489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553
            |..:||||||.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:
  Fly   576 VRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFS 640

Human   554 YIGVSVVLFLVSRFSPYEW-----------------HTEEFED---------------------G 580
            |||||:|||.||||||:||                 |.|:..:                     |
  Fly   641 YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPG 705

Human   581 RET--------------------QSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 625
            .:|                    .||...|||.::||.||||.||||||||:||||:||||....
  Fly   706 AQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAAS 770

Human   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK 690
            |:|||||:||||||||||||||||||:||.|.|||:.|||:.||||..|||.:|||||:|.:.:|
  Fly   771 WFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNK 835

Human   691 MWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 755
            ||.||.|.: .|||.|..||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:||
  Fly   836 MWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGI 899

Human   756 ATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYIL 820
            |||.||:|:.|:|||||.|.|.|.|.||:|||||:|.||.....| :...|.||||||||:||||
  Fly   900 ATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYIL 963

Human   821 VGGLGLAMLVALIEFCYKSR 840
            :|||.:::.||::|:|::||
  Fly   964 IGGLLVSVFVAILEYCFRSR 983

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 129/445 (29%)
PBP2_iGluR_AMPA 413..794 CDD:270433 245/441 (56%)
Glutamate binding 499..501 0/1 (0%)