back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIA2 and GluRIID

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	901	Identity:	296/901 - (32%)
Similarity:	476/901 - (52%)	Gaps:	92/901 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    23 SSNSIQIGGLFPRGADQEYSAFR--VGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGV 85
            |..||::|.:.....|:....|.  :.:|. :.....|....:.:...||.......|.....||
  Fly    30 SGQSIRLGLITDDATDRIRQTFEHAISVVN-NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGV 93

Human    86 YAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRP---DLKGALLSLIEYYQWDK 147
            .|:||...:.:.:.:.:.|.:..:.||.|.. :.|::|....:.|   |:..||..::..::|.:
  Fly    94 GAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWSR 157

Human   148 FAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NINNDKKDEMYRSLFQDLELKKERRVILDC 211
            |.:.|:|...|..|..::.....|...:..:... |:|.:     |:|:.:.:...::.|:::..
  Fly   158 FIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGN-----YKSVLRRIRKSEDSRIVVVG 217

Human   212 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIER 276
            ....|.:::.|...:|...:.|.|||.||.....||.:.::..||::|.::...|...|...:|:
  Fly   218 STTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEK 282

Human   277 -WSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNL--RKQRIEISRRGN----AGDCLANP 334
             ...|.|.|...:.:|.|....|||||||:|:.|..::|  :.|.:..|.|.:    .|....|
  Fly   283 LHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRN- 346

Human   335 AVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE-------V 392
                     ..|:| :::.:.::|.|.|:.|.:: .:|.:::||:|:|..|:|.|.|       .
  Fly   347 ---------YMRSL-EIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQR 400

Human   393 DKMVVTLTELPSGNDTSGLENKT-VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKH 456
            ....|...::..|:    |.||| :|:.::...||..:.::.:.|.||.:::||.|||..|:|..
  Fly   401 PPQAVNFNDIDDGS----LVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADK 461

Human   457 CGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI 521
            .||.:... .|...||:.:..|...:||:.|:|.|:||:||..||||..||||||||.|||:|||
  Fly   462 LGFNFTFR-DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGI 525

Human   522 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEFEDGR 581
            :|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||.|
  Fly   526 AILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPE--- 587

Human   582 ETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646
                 |..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||
  Fly   588 -----ELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLT 647

Human   647 VERMVSPIESAEDLS-KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEG 710
            :|...|||.|.:||: .:.::.||...:|||:.||..|:..::.||..|: :|.|.:.:....:|
  Fly   648 IENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQG 711

Human   711 VARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLS 775
            |.:| ||..|||:|:|||..|:...|: |:..|||..||.||||||..|....|...|.|:|:|.
  Fly   712 VDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQ 774

Human   776 EQGVLDKLKNKWWYD--KGECGAK--DSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC 836
            |||||.:||||||.:  .|.|.||  |.|..|    |.:.|::|::.:||.|..::::::::.:|
  Fly   775 EQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE----LGVDNLSGIYVVLVIGSIISIIISILCWC 835

Human   837 YKSRAEAKRMKV----------------------AKNAQNINPSSSQNSQNFATYK 870
            |....:||..:|                      .|:||:|...|..:||:..:.|
  Fly   836 YFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLK 891

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.