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Protein Alignment GRIA2 and CG11155

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	868	Identity:	325/868 - (37%)
Similarity:	482/868 - (55%)	Gaps:	58/868 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     4 IMHISVLLSPVL-WGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEV 67
            |:.||..|.||: .|.||........|...|      :|:.:|:...:......:|...|:.:..
  Fly    32 ILVISNALPPVIRVGAIFTEDERESSIESAF------KYAIYRINKEKTLLPNTQLVYDIEYVPR 90

Human    68 ANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-GTHPFVIQMRPD 131
            .:||..|...|||...||.||||..|....:.:.|.|....:..|......: .:..|.|.:.|.
  Fly    91 DDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINLYPS 155

Human   132 ---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYR 193
               |..|...::.|..|.|.|.:|:.|.||..|   :.|:.|.|.::..       .....:.||
  Fly   156 HTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNL---MHSSTETKAEMYI-------RQASPDSYR 210

Human   194 SLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVS 258
            .:.:.:..|:..::|:|.....:......::.:..:...|||:.........||...::...|::
  Fly   211 QVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNIT 275

Human   259 GFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTT----IKYTSALTYDAVQVMTEA--FRNL-RK 316
            .|::||.|.   .:::|..:.:::.::.|..|..    |:..|||.:|:|......  |.|| ..
  Fly   276 AFRLVDVDS---KRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNH 337

Human   317 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTN 381
            |...|.......|      ..|..|:.:...:.....:||:|.::|.: |:|..:.::|::||..
  Fly   338 QNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQE 395

Human   382 GPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYC 446
            ..:|:|||...|.  |.::: |:....|.:.|.|:||.|..|.||||:|:: :.|.||.|:||:|
  Fly   396 KIQKVGYWHPDDG--VNISD-PTAFYDSNIANITLVVMTREERPYVMVKED-KNLTGNLRFEGFC 456

Human   447 VDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVID 511
            :||...||...||:||:.:|.|..||....:|..|||:|.||:..:||:|:|.:||...||.|||
  Fly   457 IDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVID 521

Human   512 FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEE 576
            |:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|||||||....
  Fly   522 FTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPH 586

Human   577 FEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 641
             ...:||...|  |:|.|.||.||..|.|::||..::|::.|.|||||.|:||.|||||||||||
  Fly   587 -PCYKETDIVE--NQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANL 648

Human   642 AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRT 706
            |||||||||:||||||.||::||||:||||:.|||..|||.|||.::.|||.||.:.:.:|||:|
  Fly   649 AAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKT 713

Human   707 TAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAV 771
            ..:|:.||  .:|.||:|:||||.:|..|| .|:..::||.||||||||||||||..|..::||:
  Fly   714 YEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAI 775

Human   772 LKLSEQGVLDKLKNKWWYDKGE-CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835
            |:|.|:|::..|.:|||.:.|: |...|...:.|.:||.:.|:.|||.:|:.||.||::||:.||
  Fly   776 LELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEF 840

Human   836 CYKSRAEAKRMKVAKNAQNINPS 858
            |:.||         ||....|.|
  Fly   841 CWNSR---------KNLNTENQS 854

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.