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Protein Alignment GRIA2 and Ekar

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	308/876 - (35%)
Similarity:	483/876 - (55%)	Gaps:	78/876 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    27 IQIGGLF---PRGADQE----YSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84
            ::||.:|   |...:.|    |:..|:.|.:....|..:..:::.:...:||......|.....|
  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRVG 87

Human    85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPD---LKGALLSLIEYYQWD 146
            |.|:|...|......|.|.|..|.:..|..|     .|.|.|.:.|.   :..|...:|:|..|.
  Fly    88 VQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINVYPSKQLVNYAFNDVIQYLNWT 147

Human   147 KFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDC 211
            :|..|::.:.|:..|..:..|...:      :::..::.|.    |.|...:.:.|:...:|:|.
  Fly   148 RFGILHEKENGIINLHQLSRSFHGE------VHMRQVSRDS----YVSALNEFKGKEIHNIIIDT 202

Human   212 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIER 276
            ..:.::.::..::....:...|||:..:......||...::...|::.|::||..|..|.:.::.
  Fly   203 NSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKD 267

Human   277 WST----LEEKEYPGAH---TTTIKYTSALTYDAVQVMTEAFRNLRKQR----IEISRRGNAGDC 330
            ...    :.:|.|...|   :|.::...||.:|:|.|.....:.|.:..    :.||       |
  Fly   268 IGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS-------C 325

Human   331 LANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395
            ....:  |..|:.:...|..|:.:||:|.|:| ::|:|:.:.:::::||.:...|:|.|:....:
  Fly   326 EEENS--WDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHL 387

Human   396 VVTLTELPSGNDTSGLENKTVVVTTILESPYVMMK--KNHEMLEGNERYEGYCVDLAAEIAKHCG 458
              .:|| ||....:|..|.|:||.||||:|||||.  ||   ..||||:.|:|||:...|::..|
  Fly   388 --NITE-PSMFFDAGSMNVTLVVITILETPYVMMHYGKN---FTGNERFYGFCVDILETISREVG 446

Human   459 FKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISI 523
            |.|.|.:|.|.||||:|.:|..|||||.:|:..|||:|:..:|||..||.||||:||||:|||||
  Fly   447 FDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISI 511

Human   524 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSES 588
            :.|.|......:|||::|||.|||:.::.||..||:.:::|.:.||.||   :..:..:.::...
  Fly   512 LFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW---KCINACDLENISI 573

Human   589 TNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 653
            .|:|.:.:|.||::|.||||..||.||::|.||:...|.||:|||::|||||||||||.|||::|
  Fly   574 GNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINP 638

Human   654 IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSK 718
            ||:||||:.||||:|||||||||..|||.|.|..:.|:|..|.:.:||.|..|..:|:.||  ::
  Fly   639 IENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQ 701

Human   719 GKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKL 783
            |.||:|:||||.:||.|| .|:..::||.||:|||||||||||..|..::||:|:|.|:|.:..|
  Fly   702 GNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQML 765

Human   784 KNKWWYDKGE-CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847
            .:|||.:..| |..|::..:.|.::|.|.::.|||.:|:.|:.:|.:||..||.|..|
  Fly   766 YDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR------- 823

Human   848 VAKNAQNINPSSSQNSQNFATYKEGYNVYGI 878
                 .|...:.||:..|     ..||..||
  Fly   824 -----YNYEATPSQSVVN-----NKYNQDGI 844

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.