Protein Alignment GRIA2 and Grik

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 858
• Identity: 280/858 - (32%)
• Similarity: 434/858 - (50%)
• Gaps: 99/858 - (11%)

Human    64 NLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFIT------PSFPTDGTH 122
            ::|..|||..:...|....:.:.|:||.....:.....|.|....:.|:.      ...||...|
  Fly    73 SIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLH 137

Human   123 PFVIQMRPDLKG-ALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLD-------SAAEKKWQVTAIN 179
            |     .|...| ||..::....|:.|..:|:|...|.|::.:|.       :...:::::
  Fly   138 P-----HPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYEL---- 193

Human   180 VGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTD 244
              ::|.:     ||::.:.:....:...::......:.:...|...:|.....|.|||.||.:..
  Fly   194 --DLNGN-----YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHT 251

Human   245 GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTT-TIKYTSALTYDAVQVMT 308
            .||...|..|.|::|.::|..|...|.:..:   .|.|.|.|..:.: .:..:.||.||.||::.
  Fly   252 MDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYESEEPFQNVSCPLTNSMALVYDGVQLLA 313

Human   309 EAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTI 373
            |.::::..:.:.:|         .|....|.:|..:...:|.:.:.||:|.|:||..|.|.::.:
  Fly   314 ETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKL 369

Human   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGN---DTSGLENKTVVVTTILESPYVMMKKNHEM 435
            .::||..:|.:|||.||..|..... ...|:.:   |...|.||:.||.|.:..||.|:|:..|.
  Fly   370 EVIELAVSGMQKIGQWSGEDGFQEN-RPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEK 433

Human   436 LEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500
            ||||:::||:.::|..|::|..||.|...:..|.|||..|..|..||||:.|::..:||:.|..|
  Fly   434 LEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDL 498

Human   501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 565
            |:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.
  Fly   499 TMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG 563

Human   566 RFSPYEWHT-----EEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 625
            |.||.||..     ||        .:|..|:|...|.||||:||.:|||.:::|::.|.|.|...
  Fly   564 RLSPAEWDNPYPCIEE--------PTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAAS 620

Human   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSK-QTEIAYGTLDSGSTKEFFRRSKIAVFD 689
            |||||||::||||||||||||||.:|:||..|:|||| :..:.||....|:|..||:.|....:.
  Fly   621 WWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQ 685

Human   690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 754
            :|:.:||. .|.....|..|||.||..|  .||:|:|||..|||.:|: |...:||..||.||||
  Fly   686 RMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYG 746

Human   755 IATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGA-----KDSGSKEKTSALSLSNVA 814
            ||..|....|..::.|||::.|||:|.|:|.|||.:|...||     :|||:    .||.:||:.
  Fly   747 IAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGA----VALEISNLG 807

Human   815 GVFYILVGGLGLAMLVALIE-------------------------FCYKSRAEAKRMKVAKNAQN 854
            |||.::..|....:.|:|:|                         |..:.....|.:|..||:..
  Fly   808 GVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSR 872

Human   855 INPSSSQNSQNFA 867
            .|.||.....:.:
  Fly   873 SNASSKSKGSSMS 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	79/348 (23%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	174/386 (45%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877		0/1 (0%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	79/350 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	172/381 (45%)