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Protein Alignment GRIA2 and KaiR1D

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	339/863 - (39%)
Similarity:	508/863 - (58%)	Gaps:	78/863 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    27 IQIGGLFPRGADQEYSAFRVGMVQFSTS-----EFRLTPHIDNLEVANSFAVTNAFCSQFSRGVY 86
            |:|||||....|.:..|||..:.:.:..     ..:|...|:.:...:||......|...:.||.
  Fly    30 IKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVA 94

Human    87 AIFGFYDKKSVNTITSFCGTLHV--------------SFITPSFPTDGTHPFVIQMRPDLKGALL 137
            ||||.....:.:.:.|.|..:.:              |.:...:|    ||      ..|..|.:
  Fly    95 AIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYP----HP------NTLSKAYV 149

Human   138 SLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELK 202
            .::.::.|..|..:|:::.|:..||.:|.:.....:.:|...:    :|..|  ||.|.:.::..
  Fly   150 DIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQL----SDSGD--YRPLLKQIKNS 208

Human   203 KERRVILDCERDKVNDIVDQVITIGKHVKGYH-YIIANLGFTDGDLLKIQFGGANVSGFQIVDYD 266
            .|..::|||..:::::::.|...||. :..|| |::.:|.....:|.:.::||.|::||:::  :
  Fly   209 AEAHIVLDCSTERIHEVLKQAQQIGM-MSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI--N 270

Human   267 DSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDC 330
            :.:||..:.:||..|:.....|:.||::..:||.||||.:..:|..:| ..|:|:|......|..
  Fly   271 EKIVSDVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPISCDGQS 335

Human   331 LANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395
                  .|..|..:...:|.|:::||:..||||..|.|.::.::|:||...|.||||.|:
  Fly   336 ------TWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN----- 389

Human   396 VVTLTELPSG-NDT-----------SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVD 448
                :.||.| |.|           :.|:|||:||||||.:||.|.|::...|.||:::|||.||
  Fly   390 ----STLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVD 450

Human   449 LAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS 513
            |..||:|..||.||:.:|.||.||:.:..|..||||:.||:..:||:|||.||||..||:.:||:
  Fly   451 LIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFT 515

Human   514 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE 578
            .|||:||:||:.:||.|..|.:||||.||:.::|:.:..||:||||:||::::|:||||......
  Fly   516 TPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWPAYTDA 580

Human   579 DGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 643
            .|.:.:|     :|.:.|.:||::|:.||||||..|::||.|:|.|:|||||||:||||||||||
  Fly   581 HGEKVES-----QFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAA 640

Human   644 FLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708
            |||||||.|||||||||:|||.|.||.|..|||..|||.|||:.:.:||::|.||.||||..:..
  Fly   641 FLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNG 705

Human   709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLK 773
            |||.||.|.||.||:|:|||..||:.:|. |:..:|||.||:|.||||||..|..||.:|..:||
  Fly   706 EGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAINSVILK 769

Human   774 LSEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835
            |.|:|.|..||.|||.:|   |:|..:.|.|....:.|.|:||.|||.:|:||:|:|.::|:.||
  Fly   770 LQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEF 834

Human   836 CYKSR--AEAKRMKVAKN 851
            .:|||  |..:|:....|
  Fly   835 VWKSRKVAVEERLSAILN 852

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.