Protein Alignment GRIA2 and Ir84a

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 663
• Identity: 139/663 - (20%)
• Similarity: 253/663 - (38%)
• Gaps: 147/663 - (22%)

Human   234 HYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSA 298
            |.::......||| .||:.....::.:::..|...:.:.|       |:..:.|:..|
  Fly    49 HVLVVRGDDADGD-WKIECHQKLLANYRVQFYRPEMSANF-------EDLMFYGSPRT------- 98

Human   299 LTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW---GQGVE---IERALKQVQVEGLS 357
                ||.|:......:|:|...::  ..||  ..|.::.|   |.|.|   :|:.:.|:    ||
  Fly    99 ----AVLVLNSEHVLVRRQVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQL----LS 151

Human   358 G-----------NIKFDQNGKRINYTINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDT 408
            |           .::...|...:.|.:..:..:.|.|   .|.|.|:.           ..|...
  Fly   152 GYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTH-----------SGGYQK 205

Human   409 SG------------LENKTVVVTTIL-ESP-------YVMMKKNHEMLEGNERYEGYCVDLAAEI 453
            .|            ..|.|::.:|:| |.|       |:...|..:.|:..:|.......|...:
  Fly   206 FGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM 270

Human   454 AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518
                 |...|.|....|:|.. .|...|:|::|::...:||.|:.|:...|.|:..:.:|....:
  Fly   271 -----FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHT 329

Human   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583
            ..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|.              |.
  Fly   330 QNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRL--------------ER 379

Human   584 QSSESTNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLA 642
            ..|...|.|..   :||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:.
  Fly   380 MLSNMENRFSF---VWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIV 437

Human   643 AFLTVE--RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT--YMRSAEPSVF 703
            ..|..|  |.:..:::..|    :.:|.|..:.......|..:...:...::.  ..:|.|.::.
  Fly   438 GSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM 498

Human   704 VRTTAEGVARVRKSKGKYAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIA 756
              :..:|..|:  .:|::|:          |||..|:|    .:.||..:|..||  ||   |..
  Fly   499 --SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSV 552

Human   757 TPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 821
            .||||..|..:..|:|.....|:|.....||...:.:|    |..|...:.:.|.:.|...:.|.
  Fly   553 MPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTSQAEVDLEHFAPALFALA 613

Human   822 GGLGLAMLVALIE 834
            ..:..:.||.|:|
  Fly   614 LAMVASALVFLLE 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	35/183 (19%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	92/410 (22%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	13/76 (17%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	19/74 (26%)
		Lig_chan	353..602	CDD:459656	62/288 (22%)