DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir84a

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_649720.2 Gene:Ir84a / 40891 FlyBaseID:FBgn0037501 Length:644 Species:Drosophila melanogaster


Alignment Length:663 Identity:139/663 - (20%)
Similarity:253/663 - (38%) Gaps:147/663 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   234 HYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSA 298
            |.::......||| .||:.....::.:::..|...:.:.|       |:..:.|:..|       
  Fly    49 HVLVVRGDDADGD-WKIECHQKLLANYRVQFYRPEMSANF-------EDLMFYGSPRT------- 98

Human   299 LTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW---GQGVE---IERALKQVQVEGLS 357
                ||.|:......:|:|...::  ..||  ..|.::.|   |.|.|   :|:.:.|:    ||
  Fly    99 ----AVLVLNSEHVLVRRQVFGVA--SEAG--YFNNSLAWFILGSGRESLPVEQLIDQL----LS 151

Human   358 G-----------NIKFDQNGKRINYTINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDT 408
            |           .::...|...:.|.:..:..:.|.|   .|.|.|:.           ..|...
  Fly   152 GYRMGIDADITVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTH-----------SGGYQK 205

Human   409 SG------------LENKTVVVTTIL-ESP-------YVMMKKNHEMLEGNERYEGYCVDLAAEI 453
            .|            ..|.|::.:|:| |.|       |:...|..:.|:..:|.......|...:
  Fly   206 FGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADDKQLQQLDPMQRKTYQLFQLVERM 270

Human   454 AKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518
                 |...|.|....|:|.. .|...|:|::|::...:||.|:.|:...|.|:..:.:|....:
  Fly   271 -----FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHT 329

Human   519 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRET 583
            ..|..:.:.|::|..... |.:||:.::|.|::....|.:::|....|.              |.
  Fly   330 QNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTILLLFHVRL--------------ER 379

Human   584 QSSESTNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSGRIVGGVWWFFTLIIISSYTANLA 642
            ..|...|.|..   :||: |..::|||    |     |..|.|::..:...|:.:::..|.|.:.
  Fly   380 MLSNMENRFSF---VWFTMLETYLQQG----PANEIFRLFSTRLLISLSCIFSFMLMQFYGAFIV 437

Human   643 AFLTVE--RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT--YMRSAEPSVF 703
            ..|..|  |.:..:::..|    :.:|.|..:.......|..:...:...::.  ..:|.|.::.
  Fly   438 GSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIM 498

Human   704 VRTTAEGVARVRKSKGKYAY----------LLESTMNEYIEQRKPCDTMKVGGNL--DSKGYGIA 756
              :..:|..|:  .:|::|:          |||..|:|    .:.||..:|..||  ||   |..
  Fly   499 --SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE----AEFCDLQEVMFNLPYDS---GSV 552

Human   757 TPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 821
            .||||..|..:..|:|.....|:|.....||...:.:|    |..|...:.:.|.:.|...:.|.
  Fly   553 MPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC----SLFKTSQAEVDLEHFAPALFALA 613

Human   822 GGLGLAMLVALIE 834
            ..:..:.||.|:|
  Fly   614 LAMVASALVFLLE 626

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 35/183 (19%)
PBP2_iGluR_AMPA 413..794 CDD:270433 92/410 (22%)
Glutamate binding 499..501 1/1 (100%)