Protein Alignment GRIA2 and Nmdar1

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 1000
• Identity: 258/1000 - (25%)
• Similarity: 421/1000 - (42%)
• Gaps: 239/1000 - (23%)

Human     7 ISVLLSPVLWGLIFGVSSN--SIQIGGLFPRGADQEYSAFRVGMVQF-------STSEFRLTPHI 62
            |.:|::|:........|.|  :..|||:......:|:.:..:..:.|       ..:.:..|..:
  Fly    17 IVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRM 81

Human    63 DNLEVANSFAVTNAFCSQ-FSRGVYAIF-------------------GFYDKKSVNTI------T 101
            |...:...|.|    |.: ....|||:.                   |||   |:..|      .
  Fly    82 DKNPIKTVFNV----CDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFY---SIPVIGISSRDA 139

Human   102 SFCG-TLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVL 165
            :|.. .:||||:. :.|     |:..|     ....|.::.::.:.|...::.||   :..:|:|
  Fly   140 AFSDKNIHVSFLR-TVP-----PYYHQ-----ADVWLEMLSHFAYTKVIIIHSSD---TDGRAIL 190

Human   166 DSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHV 230
            .     ::|.|:               ::.:.|::::....:|::.| .|:....:.:|.: |..
  Fly   191 G-----RFQTTS---------------QTYYDDVDVRATVELIVEFE-PKLESFTEHLIDM-KTA 233

Human   231 KGYHYII------ANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPG-- 287
            :...|::      |.:.|.|.       |..|::|...|             |...|:..:..
  Fly   234 QSRVYLMYASTEDAQVIFRDA-------GEYNMTGEGHV-------------WIVTEQALFSNNT 278

Human   288 -----------AHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQG 341
                       ||:     ......|:|.|:..|.:.:...........:.||    .||.|..|
  Fly   279 PDGVLGLQLEHAHS-----DKGHIRDSVYVLASAIKEMISNETIAEAPKDCGD----SAVNWESG 334

Human   342 VEIERALKQVQVEGLSGNIKFDQNGKRI--NY-TINIME-LKTNGPRKIGYWSEVDKMVVTLTEL 402
            ..:.:.||...:.|.:|.:.||.||.||  .| .|||.| .|.:...|..|.|...||.:.:
  Fly   335 KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRI--- 396

Human   403 PSGNDT------------SGLENKT-VVVTTILESPYVMMKK------------------NHEML 436
               ||:            .|:...| :.:.||.|.|:|.:::                  |:...
  Fly   397 ---NDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDA 458

Human   437 EGNE-RYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG------ARDADT--KIWNGMVGELVYGK 492
            ..|| ...|||:||..|::|...|.|.|.:..||::|      ...|.|  |.|.|::||||..:
  Fly   459 TANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNER 523

Human   493 ADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 557
            ||:.:|||||...|.|.|:|||||...||:|:.|||.:|.. :.|||.|.:..:|:.::.:...|
  Fly   524 ADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFSNTLWILVMVSVHVV 587

Human   558 SVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE---FGIFNSLWFSLGAFMQQGC-DISPRSLS 618
            ::||:|:.||||:         ||...|...:||   ..:.:::||:.|..:..|. :.:|||.|
  Fly   588 ALVLYLLDRFSPF---------GRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFS 643

Human   619 GRIVGGVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLSKQTEIAYGTLDSGSTKEFF 680
            .|::|.||..|.:||::||||||||||.:||   .:|.|..|...:....:...|:...|...:|
  Fly   644 ARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYF 708

Human   681 RRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVG 745
            ||..     ::....|:.|.:.:. |..:.:..|:|.| ..|::.:|:..|| |..|.|:.:..|
  Fly   709 RRQV-----ELSNMYRTMEANNYA-TAEQAIQDVKKGK-LMAFIWDSSRLEY-EASKDCELVTAG 765

Human   746 GNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSK--EKT-SA 807
            ......||||...|||.....|.||:|:..|.|.::||..:|.:.    |......:  ||| :.
  Fly   766 ELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFH----GHVQQNCELFEKTPNT 826

Human   808 LSLSNVAGVFYI----LVGGLGLAMLVALIEFCYKSR--AEAKRMKVAKNA-----------QNI 855
            |.|.|:||||.:    :.||:||    .:||..||..  .:.||:.:|::|           :.|
  Fly   827 LGLKNMAGVFILVGVGIAGGVGL----IIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTI 887

Human   856 NPSSSQNSQNFATYKEGYNVYGIES 880
            ..|.:...|        ||| |:.|
  Fly   888 RASLAMQRQ--------YNV-GLNS 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	83/426 (19%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	136/415 (33%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877		3/9 (33%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	85/445 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	137/422 (32%)
		CaM_bdg_C0	854..882	CDD:402271	6/27 (22%)