DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir76b

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_649176.1 Gene:Ir76b / 40198 FlyBaseID:FBgn0036937 Length:636 Species:Drosophila melanogaster


Alignment Length:589 Identity:132/589 - (22%)
Similarity:220/589 - (37%) Gaps:150/589 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTS--GLENKTVVVTTILESPYVMMKKNHEML 436
            |::::..||            .:..:||||...|.|  |.:....|.|  ||:......|..|||
  Fly    27 NLIQMGENG------------TLSPVTELPMDVDASEAGFDADAPVET--LETINRKKPKLREML 77

Human   437 E-------------------------GNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RD 475
            :                         |.....|....:...:.|...|.|::.:..|...|: .|
  Fly    78 DWIGGKHLRIATLEDFPLSYTEVLENGTRVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSPSD 142

Human   476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI-KKPQKSKPGVFSFL 539
            .|..:.. ||..   ...|:|.|.:.....:...:.:|...:..|..||: ::|::|..| ...|
  Fly   143 FDRSLIE-MVNS---STVDLAAAFIPSLSDQRSFVYYSTTTLDEGEWIMVMQRPRESASG-SGLL 202

Human   540 DPLAYEIWMCIVFAYIGVSVVLF----LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600
            .|..:.:|:.|:.:.:.|..:::    |.:|.:         .||::|       .:.:.:..||
  Fly   203 APFEFWVWILILVSLLAVGPIIYALIILRNRLT---------GDGQQT-------PYSLGHCAWF 251

Human   601 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTE 665
            ..||.|:||..:||.:.|.|::...||.|..|:.|.|||||.||||:.:...|            
  Fly   252 VYGALMKQGSTLSPIADSTRLLFATWWIFITILTSFYTANLTAFLTLSKFTLP------------ 304

Human   666 IAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARV-RKSKGKYAYLLEST- 728
              |.|::...||           :|.:..||.......:|||.|.::.: |..:..||...:.| 
  Fly   305 --YNTVNDILTK-----------NKHFVSMRGGGVEYAIRTTNESLSMLNRMIQNNYAVFSDETN 356

Human   729 ----MNEYIEQ--------RKPCDTM--------KVGGNLDSKGY---------------GIATP 758
                :..|:|:        |...:.|        |.....|.|.:               ..|.|
  Fly   357 DTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLKKKRTFAYP 421

Human   759 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGG 823
            .||:|....:..:|.|.|.|::..| :|......|...:|.|..|:  .|...::...:||::.|
  Fly   422 IGSNLSQLFDPELLHLVESGIVKHL-SKRNLPSAEICPQDLGGTER--QLRNGDLMMTYYIMLAG 483

Human   824 LGLAMLVALIEFCYK---SRAEAKR-----MKVAKNAQNINPS---------SSQNSQNFATYKE 871
            ...|:.|...|..::   ||.||.:     :....|.|::.||         :|.:.|.......
  Fly   484 FATALAVFSTELMFRYVNSRQEANKWARHGIGRTPNGQSVAPSRWLRGWRRLNSGHGQLLGASTH 548

Human   872 GYNV 875
            |.||
  Fly   549 GQNV 552

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 3/23 (13%)
PBP2_iGluR_AMPA 413..794 CDD:270433 98/448 (22%)
Glutamate binding 499..501 0/1 (0%)