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Protein Alignment GRIA2 and Ir75a

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	677	Identity:	126/677 - (18%)
Similarity:	239/677 - (35%)	Gaps:	182/677 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   207 VILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQ----FGGANVSGFQIVDYDD 267
            :.:|.:.|:..|::::......:.:.||:::.      |:..|::    ||..|:|    :|.|.
  Fly    79 IYVDIKCDQTQDLLEEASREQIYNQHYHWLLV------GNQSKLEFYDLFGLFNIS----IDADV 133

Human   268 SLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLA 332
            |.|            ||....:..::.|.....|:
  Fly   134 SYV------------KEQIQDNNDSVAYAVHDVYN------------------------------ 156

Human   333 NPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVV 397
                                            |||.|...:|:     .|..::.....|.:...
  Fly   157 --------------------------------NGKIIGGQLNV-----TGSHEMSCDPFVCRRTR 184

Human   398 TLTELPSGNDTSGLENKTVVV----TTILESPYV---------MMKKNHEMLEGNERYEGYCVDL 449
            .|:.|...:.....|..|.||    |.:.:.|..         :.::|...::...|: |:.:.|
  Fly   185 HLSSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTHIDSLARF-GFHLTL 248

Human   450 AAEIAKHCGFKY-------KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVRE 507
            ......||..|:       |..:||               |.||.:|...||:...|   :|..|
  Fly   249 ILRDLLHCKMKFIFSDSWSKSDVVG---------------GSVGAVVDQTADLTATP---SLATE 295

Human   508 EVIDFSKPFMSLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVS 565
            ..:.:....:..|.  |:.| :.|..:......||.|.:..:|...  |.:.|||.  :..::..
  Fly   296 GRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMEC 360

Human   566 RFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 630
            :.....|..:...              .:.::...|.||...|...:.|||..||::     :|.
  Fly   361 KRMQKRWRLDYLP--------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFA 406

Human   631 LIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTEIAYGTLDSG-----STKEFFRRSK---IA 686
            |.:||....|....:.|..:: ||::|  .:....::|..:|..|     .||.:...|:   |.
  Fly   407 LFLISFIMYNYYTSVVVSSLLSSPVKS--KIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIH 469

Human   687 VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLEST-----MNEYIEQRKPCDTMKVGG 746
            :|.|.....::..|.::: ...:||.|||.:.| |.|:.|::     :..|...::.||..:|..
  Fly   470 LFIKRKIESQTQNPELWL-PAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLF 532

Human   747 NLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLS 811
            ..:...| ....:.|:.:....|..|::.|.||..|.::.|.:.|..|.|::.     ...:.:.
  Fly   533 RPEQLFY-THLHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-----VITVGME 591

Human   812 NVAGVFYILVGGLGLAMLVALIEFCYK 838
            .||.:..:|:....|.:::.|:|..:|
  Fly   592 YVAPLLLMLICADILVVVILLVELAWK 618

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.