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Protein Alignment GRIA2 and Ir68a

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	134/719 - (18%)
Similarity:	245/719 - (34%)	Gaps:	219/719 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   198 DLELKKERRVILDCERDKVNDIVDQVITI--GKHVK---GYHYIIANLGFTDGDLLKIQFGGANV 257
            ||: :..|:|.|..:..|.:|....||||  |..|:   ||.|        |...|.:|.....:
  Fly    91 DLQ-RPSRQVELFVKAIKSSDCELNVITILNGWQVQRFLGYIY--------DNRSLNMQKKFVLL 146

Human   258 SGFQIVDYDDSLVSKFIERWSTLEE-----KEYPGAHT-TTIKYTSALTYDAVQVMTEAFRNLRK 316
            ...::.:.|      .|..||...:     ::....:| :||.:...|:  .|.||..
  Fly   147 HDLRLFESD------MIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILS--GVLVMKN------- 196

Human   317 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTN 381
                          :||    |..|            :||:|.|.|
  Fly   197 --------------IAN----WELG------------KGLNGRILF------------------- 212

Human   382 GPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYC 446
                      .||             ||.|...::.|......|.|:      .....:.::|..
  Fly   213 ----------ADK-------------TSNLFGTSLPVAISEHVPMVL------WANATKSFQGVE 248

Human   447 VDLAAEIAKHCGFK---YK--------LTIVGDG---KYGARDADTKIWNG------MVGELVYG 491
            |::...:.|...||   ||        .|.:..|   .||:.:.|....||      :|.|:...
  Fly   249 VEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAH 313

Human   492 KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF-SFLDPLAYEIWMCIVFAYI 555
            .|..||..|.:..|..::::.|.|.....::.:  .|:.|....: :|:.|.:..:|:.::.:..
  Fly   314 SARFAIGDLHLFQVYLKLVELSAPHNFECLTFL--TPESSTDNSWQTFILPFSAGMWVGVLLSLF 376

Human   556 GVSVVLFLVS------------------------RFSPYEWHTEEFEDG----RETQSSESTNEF 592
            .|..|.:.:|                        ...|..:....|...    |.::......:.
  Fly   377 VVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDL 441

Human   593 --GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 655
              |..|.:..:....:.......||:...|::.|.:|.:.::::::|.|:..|.|........|:
  Fly   442 FDGYTNCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTID 506

Human   656 SAEDLSKQTEIAYGTLDSGST--KEFF--RRSKIA--VFDKMWTYMRSAEPSVFVRTTAEGVARV 714
            :.|||.: :.|...|   |:|  ::||  ...::|  |.:||..:..|.:            ...
  Fly   507 TLEDLLR-SHIPPST---GATENRQFFLEANDEVARKVGEKMEVFGYSDD------------LTS 555

Human   715 RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG--------------IATPKGSSLRT 765
            |.:||:.||........|:..            .|..|..              :|..|.|:|:.
  Fly   556 RIAKGQCAYYDNEFYLRYLRV------------ADESGSALHIMKECVLYMPVVLAMEKNSALKP 608

Human   766 PVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLV 830
            .|:.::..|:|.|::    .||..|..|....::.:::: :.:::......|..|:.|..::||.
  Fly   609 RVDASIQHLAEGGLI----AKWLKDAIEHLPAEALAQQE-ALMNIQKFWSSFVALLIGYVISMLT 668

Human   831 ALIE 834
            .|.|
  Fly   669 LLAE 672

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.