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Protein Alignment GRIA2 and GluRIA

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	914	Identity:	378/914 - (41%)
Similarity:	529/914 - (57%)	Gaps:	124/914 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    24 SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84
            :..|.:|.:|.:|.|...|||:..|    :..|:..|.|..::|.:..|::|.::...|:|||||
  Fly    37 TEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRG 101

Human    85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTDGTHPFVIQMRPDLKGALLSLIEYY 143
            ||::.|.....|.:|:.|:..|..:.|:||.|      |:.|...|.|.||||...|::..|:||
  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYY 166

Human   144 QWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVI 208
            .|....|||||..||..||.:...............|..|.|......:....:||....::|::
  Fly   167 GWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIV 231

Human   209 LDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTD---GDLLKIQFGGANVSGFQIVDYDD 267
            |||..:...:|:.|   .|.:|:  :.|||:::.|...:   .|:  ::||..|::||:|||.:.
  Fly   232 LDCPAEMAKEIIVQHVRDIKLGR--RTYHYLLSGLVMDNHWPSDV--VEFGAINITGFRIVDSNR 292

Human   268 SLVSKFIERWSTLE-----EKEYPGAHTT--TIKYTSALTYDAVQVMTEAF-RNLRKQRIE---- 320
            ..|..|.:....||     :.:..|...:  .|...:||.||||.|:.||| |.|||:..:
  Fly   293 RAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSN 357

Human   321 -ISRRGNAG----------------DCLANP--AVPWGQGVEIERALKQVQVEGLSGNIKFDQNG 366
             :.||.:.|                ||..:.  ..||.||.:|.|.|::|:::||||.|:||::|
  Fly   358 HLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDG 422

Human   367 KRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGL-------------------- 411
            :|||||::::|:..|.               ||.::....|.:||
  Fly   423 RRINYTLHVVEMSVNS---------------TLQQVAEWRDDAGLLPLHSHNYASSSRSASASTG 472

Human   412 ---ENKTVVVTTILESPYVMMKK--NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471
               .|.|.:|:::||.||:.:|:  ..|.|.||:|:||||.|||..:|...|.||::.:|.||.|
  Fly   473 DYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNY 537

Human   472 GARDADTK-IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535
            ||.:.... .|:||||||:..:|||||:.:|||..||.|||||||||:||||||||||.|..|||
  Fly   538 GAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGV 602

Human   536 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSEST----------- 589
            ||||:||:.|||:.::.:|:|||.||:.|:||.||||...     |..|:..:.
  Fly   603 FSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIV-----RRPQADSTAQQPPGIIGGAT 662

Human   590 -------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 641
                         |||.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||
  Fly   663 LSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANL 727

Human   642 AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRT 706
            ||||||||||:||::.|||:.||::.||||..|||.||||||:|.:.:|||.|| :|.....|.|
  Fly   728 AAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHT 791

Human   707 TAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAV 771
            ..||:.|||:||||||.|:||..|||:..|.||||||||.|:|:||:|:|||.||.||..:|.||
  Fly   792 YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAV 856

Human   772 LKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC 836
            |.|.|.|.|.:::||||:||.||......|  ..:.||||||||::|||:|||.||::||::||.
  Fly   857 LTLKENGELLRIRNKWWFDKTECNLDQETS--TPNELSLSNVAGIYYILIGGLLLAVIVAIMEFF 919

Human   837 YKSR 840
            .:::
  Fly   920 CRNK 923

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.