DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir60a

DIOPT Version :10

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_611901.1 Gene:Ir60a / 37881 FlyBaseID:FBgn0034994 Length:716 Species:Drosophila melanogaster


Alignment Length:612 Identity:102/612 - (16%)
Similarity:204/612 - (33%) Gaps:183/612 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   301 YDAVQVMTEAFRNLRKQRIEISRRGNAGD---CLANPAV----PWGQGVEIERALKQV----QVE 354
            |..|....:..:.|.|::|...|..|.|.   .|.:.|.    |.|....|.:.|.::    :|.
  Fly   143 YVIVVDSVDRLKELMKKKIVEMRSWNPGARFLVLFHNATCRNRPLGVASNIFKDLMEMFYVHRVA 207

Human   355 GLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVT 419
            .|..|       ..:||.:.:.:          |:|.|:..::.:..:...:|.....|..||..
  Fly   208 LLYAN-------STMNYNLLVND----------YYSNVNCRILNVQSVGQCHDGKLYPNNAVVKA 255

Human   420 TI-------------------LESPYVMMKKNHEMLEGNE-RYEGYCVD-LAAEIAKHCGFKYKL 463
            ::                   :.:|:|    ..:.:.|.| |..|:..: |..::.:.|..:.: 
  Fly   256 SMQDYVSGFSPRNCTFFACSSISAPFV----EADCILGLEMRILGFMKNRLKFDVNQTCSLESR- 315

Human   464 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIA---PLTITLVREEVIDF---SKPFMSLGIS 522
                    |..|.... |.|::|::...:.|....   |      ..||.|.   |..::....:
  Fly   316 --------GEMDGPAN-WTGLLGKVQNNECDFVFGGYYP------DNEVADHFWGSDTYLQDAHT 365

Human   523 IMIKKPQKSKPGVFSFLDPLAYEIWMCIV-----FAYIGVSVVLFLVSRFSPYEWHT--EEFEDG 580
            ..||...: :|.            |..:|     :.:||..::|.:...|    |.|  ....:.
  Fly   366 WYIKMADR-RPA------------WQALVGIFEAYTWIGFILILIISWLF----WFTLVMILPEP 413

Human   581 RETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645
            :..|....|    ..|:|..::...:|:    .|...:.|:.......:.|.::::||:      
  Fly   414 KYYQQLSLT----AINALAVTISIAVQE----RPICETTRLFFMALTLYGLNVVATYTS------ 464

Human   646 TVERMVSPIES---AEDLSKQTEIAYGTLDSG---STKEFFRRSKIAVFDKMWTYMRSAEPSVFV 704
               :|::..:.   ...|.:.||:....:..|   .::::|...     |.||.:          
  Fly   465 ---KMIATFQDPGYLHQLDELTEVVAAGIPFGGHEESRDWFEND-----DDMWIF---------- 511

Human   705 RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGN--LDSKGYGIATP--------K 759
                            ..|.:..   |:|.|.|..:.:|.|..  |.::.|.:.:|        .
  Fly   512 ----------------NGYNISP---EFIPQSKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFP 557

Human   760 GSSLRTPVNL-------------AVLKL-SEQGVLDKLKNKWWYDK---GECGAKDSGSKEKTSA 807
            .:...:||.:             ::::| .:.|:..|:...:.|:.   ...........|....
  Fly   558 NNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFRYNNTYLNRINKMRPQFPETAIV 622

Human   808 LSLSNVAGVFYILVGGLGLAMLVALIE 834
            |:..::.|.|:|||.|...|.|..:.|
  Fly   623 LTTEHLKGPFFILVVGSCWAALTFIGE 649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 22/107 (21%)
PBP2_iGluR_AMPA 413..794 CDD:270433 68/447 (15%)
Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491 867..877
Ir60aNP_611901.1 None
Blue background indicates that the domain is not in the aligned region.

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