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Protein Alignment GRIA2 and Ir40a

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	155/791 - (19%)
Similarity:	282/791 - (35%)	Gaps:	211/791 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   183 INNDKKD------EMYRSLFQ--------------DLELKKERRVILDCERDKVNDIVDQVITIG 227
            |.||:.|      ::.|.|.|              |...:|||.|.||       |.:.::
  Fly    25 IGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLD-------DFLQRL---- 78

Human   228 KHVKGYHYIIANLGFTDGDL----LKIQFGGANVSGFQIVDYDDSL------------VSKFIER 276
             |...|..::    |:..:|    ::....|||.....|:|..:.|            :|.||..
  Fly    79 -HRSNYKSVV----FSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFY 138

Human   277 WSTLEEKEYPGAHTTTIKYTSALTYDAVQVMT----EAFRNLRKQRIEISRRGNAGDCLANPA-- 335
            |..    .:|.: :..|::...|   .|.|:|    :|||....|              |.|.
  Fly   139 WGA----RWPPS-SRVIRFREPL---RVVVVTRPRKKAFRIYYNQ--------------ARPCSD 181

Human   336 -----VPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395
                 |.|..|..:  .|:::.:  |...:....|.|...:.:.:.    :.|.    |..|...
  Fly   182 SQLQLVNWYDGDNL--GLQRIPL--LPTALSVYANFKGRTFRVPVF----HSPP----WFWVTYC 234

Human   396 VVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK 460
            ..:..|....|....:|.:.|.||.         .::|.:|              ..::||..|:
  Fly   235 NNSFEEDEEFNSLDSIEKRKVRVTG---------GRDHRLL--------------MLLSKHMNFR 276

Human   461 YK-LTIVGDGKYGARDADTKIWN----GMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLG 520
            :| :...|..:...|..|.|..|    |.:|.|..|:||..:..:.::..|.:.|:||  |.:|.
  Fly   277 FKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLA 339

Human   521 IS--IMIKKPQKSKPGVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEWHTEE 576
            .|  .....|::....: :.:.|...:||    :.|:|:   :.|:..:.::..|    .|...:
  Fly   340 DSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRR----RWANSD 399

Human   577 FEDGRE-----TQSSESTNEF----------------GIFNS-LWFSLGAFMQQGCDISPRSLSG 619
            .|...|     |...|.|...                .:|.. :||:|..|::|.|:........
  Fly   400 VEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRA 464

Human   620 RIVGGVWWF-FTLIIISSYTANLAAFLTVERMVSPIESAEDLS------------KQTEIAYGTL 671
            :.:..|:|. .|.::...|:|.|.:.........||.:.:.|.            ::...:...|
  Fly   465 KFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEML 529

Human   672 DSGSTKEFFRRSKIAVFDKMWTYMRSA---EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI 733
            ::|:  |.||        :::..||..   :|..|...:.|...::....|:...:|......:.
  Fly   530 ENGT--ELFR--------QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFF 584

Human   734 E-QRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLK----NKWWYD--- 790
            . |:...:..::...|.::...:|...|......:|..:::|.|.|:|||:.    .|.:.:
  Fly   585 NVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEA 649

Human   791 ----KGECGAKDSGSKEKT--------SALSLSNVAGVFYIL-VGGLGLAMLVALIEFCYKSRAE 842
                ||...||:|.:..:|        |.|:|..:.|.|..| ||.|. |.::.|:|..:....:
  Fly   650 TRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQ 713

Human   843 AKRMKVAKNAQ 853
            |:...:....|
  Fly   714 ARLWMLCSRLQ 724

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.