Protein Alignment GRIA2 and clumsy

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 934
• Identity: 308/934 - (32%)
• Similarity: 478/934 - (51%)
• Gaps: 90/934 - (9%)

Human     4 IMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSE--FRLTPHIDNLE 66
            :.|..::..|||    ..:..:...:|.:|....|:...|||..:.:.:..|  ..|.|.:....
  Fly     6 LTHFLLIALPVL----ADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYAN 66

Human    67 VANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFI------TPSFPTDGTHPFV 125
            ..:||.:....|:..|:||.||||.....|.:.|.|.|.||.:..|      ..|.|........
  Fly    67 TDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT 131

Human   126 IQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187
            :.:.||   |...|..:::.:.|..|..:|::|:.|..||.:|..........|...:|
  Fly   132 LNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLG------ 190

Human   188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTDGDLLK 249
            ..:.:|...::::|..:..:||.|..|.:..|:.|   :..:|::...:..::.......|:|..
  Fly   191 PGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSG 255

Human   250 IQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKE--YPGAHTTTIKYTSALTYDAVQVMTEA-- 310
            ::   ||::..:::|..|..|...:..|...|::|  |.......:|....|..|||.:.::.
  Fly   256 VE---ANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLT 317

Human   311 ----FRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINY 371
                |..|....:|..|:           .||..|..|...:|....|..:|.|.|::||:|..:
  Fly   318 ELGIFEELTAPDLECRRK-----------KPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFF 371

Human   372 TINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSG--LENKTVVVTTILESPYVMMK--KN 432
            |:..|||.::|...:..|..|:.:.| |.:........|  |.|||.:|::.|.:|::.::  :.
  Fly   372 TLRFMELNSDGFLDLATWDPVNGLDV-LNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQE 435

Human   433 HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAI 497
            .|:|.||.|||||.:||..||||...||::..:..||||||.:..|:.|:|:|.:|:.|.||:.|
  Fly   436 GEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGI 500

Human   498 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562
            ..||:|..|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||
  Fly   501 CDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLF 565

Human   563 LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWW 627
            .::|.:|.:|  |.....:|.:..|  |.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||
  Fly   566 ALARMAPDDW--ENPHPCKEPEEVE--NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWW 626

Human   628 FFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMW 692
            ||.|::::|||||||||||..|..:.|.|||||:.|::|.||.:..|||..|||.|..:.:.|||
  Fly   627 FFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMW 691

Human   693 TYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIAT 757
            |.|.||.||||.:|..|||.||:|.|..||:|:|||..||..:|| ||.:::||.||.|.||||.
  Fly   692 TAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAM 755

Human   758 PKGSSLRTPVNLAVLKLSEQGVLDKLKNKWW---YDKGECGAKDSGSKEKTSALSLSNVAGVFYI 819
            |..|..|..::.|||||.|.|.|.:||.|||   :..|.|...|....: |..|.|.||.|||.:
  Fly   756 PFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLV 819

Human   820 LVGGLGL--AMLVALIEF-----------------CYKSRA--------EAKRMKVAKNAQNINP 857
            |  ||||  ||::...||                 .:||.|        ..|.:..:..:.:.|.
  Fly   820 L--GLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNS 882

Human   858 SSSQNSQNFATYK-EGYNVYGIES 880
            |||.:|::..::| :|.::..::|
  Fly   883 SSSSSSRSKHSFKSQGLSMKSLKS 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	90/391 (23%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	179/385 (46%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877		2/10 (20%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	90/389 (23%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	177/377 (47%)