Protein Alignment GRIA2 and GluRIIB

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 890
• Identity: 242/890 - (27%)
• Similarity: 409/890 - (45%)
• Gaps: 130/890 - (14%)

Human    36 GADQEYSAFRVGMVQFSTSEFRLTP----------------HIDNLE----VANSFAVTNAFCSQ 80
            ||:::....::|.:.|.| |.:|..                .:|.::    |.:|..:.:..|..
  Fly    17 GANEDTLVIKIGAIFFDT-EMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDL 80

Human    81 FSRGVYAIFGFYDKKSVNTITSFC---GTLHVSFITPSFPTDG-----THPFVIQMRP---DLKG 134
            ...||.||||...|.:.:.:...|   |..|:.|  ...|...     .|...:.:.|   .|..
  Fly    81 IGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQF--DWHPQQSNRERMNHQLTVNVAPMELFLSA 143

Human   135 ALLSLI--EYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQ 197
            |...::  :.:.|..|...|:....|..||.:|   |.|:.....|.:...   ::.:.||.|::
  Fly   144 AFSDILASKTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIKMQEF---ERGDDYRILWK 202

Human   198 DLELKKERRVILDCERDKVNDIVDQVITIGKHVKG--YHYIIANLGFTDGDLLKIQFGGANVSGF 260
            .:...:|:.|:|||..|.:.|:::  .:||.::.|  .|..:.||   |..|       :.:.||
  Fly   203 RINNAREKFVLLDCPSDILVDVIN--ASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGF 255

Human   261 QIVDYDDSLVSKFIERWSTLEEKEYPGAH-----------TTTIKYTSALTYDAVQVMTEAFRNL 314
            ...|:..::.:..|..:..      |..|           |......|.|.||::.:...|.
  Fly   256 YSRDFTVAVAAVRIRTYVP------PPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL--- 311

Human   315 RKQRIEISRRGNAGDCLANPAVP---WGQGVEIERALKQVQVEGL-----SGNIKFDQNGKRINY 371
                :|||:|  .|..:.|.:..   |..|..:...:||:..:.:     :..::.:.:|:|.::
  Fly   312 ----LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDF 370

Human   372 TINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDTSGLENKTV-------------VVTT 420
            .:.:.     .|   |....|:: :..:|...:|.. |.|..|:.|.:             .|.|
  Fly   371 NLEVY-----NPIIDRVTHIWNK-EFQLVDFEKLRE-NSTQALKQKRLQNKEDFSQKPIRYTVAT 428

Human   421 ILESPYVMMKKNHEML--EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNG 483
            .:..||...::..|.:  |||||:|||.|||...:|:.|.|.:....|.|.|||:.||:|..|:|
  Fly   429 RVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDG 493

Human   484 MVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548
            ::.:|:...|.|.|..||||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:
  Fly   494 IIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558

Human   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDIS 613
            .::.|.:..:..|....|...|||........||   .|..|.:.:.|:||..||:.:.||||:.
  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE---MERQNIWHLSNALWLVLGSMLNQGCDLL 620

Human   614 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKE 678
            ||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..
  Fly   621 PRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSV 685

Human   679 FFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMK 743
            :|..|........|..|.|.:|..|.:...|||.||:.|||.||:|:|:|..:|..||. |:..:
  Fly   686 YFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQ 749

Human   744 VGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWW-YDKGECGAK----DSGSKE 803
            :|.:...|.||||.|..:..|:.:::.:|:|||:|.|.||:|||: .::..|.:.    |.|.
  Fly   750 IGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ-- 812

Human   804 KTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKV 848
                ..:.:|.|:|.:|:.|:.:.:::.:.||.:..:..:.:.|:
  Fly   813 ----FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	82/418 (20%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	144/396 (36%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	79/401 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	143/376 (38%)