DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and GluRIIA

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_523484.2 Gene:GluRIIA / 33788 FlyBaseID:FBgn0004620 Length:907 Species:Drosophila melanogaster


Alignment Length:922 Identity:287/922 - (31%)
Similarity:459/922 - (49%) Gaps:104/922 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     4 IMHISVLLSPVLWGLIF--GVSSNSIQIGGLFPRGADQ-EYS---AFR-VGMVQFSTSEF----R 57
            :::..:::...|.|:|.  |...|.|.:|.:|.....: |.|   ||| |..::||...|    |
  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKR 71

Human    58 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT- 121
            ..|..|      ||.:....|...|.||.||||...|.:.:.:........:..|......:.| 
  Fly    72 YMPTND------SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATR 130

Human   122 -----HPFVIQMRPD---LKGALLSLIE-YYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTA 177
                 |...|.:.|.   |..|...:|: .|:|..|..:|::..||:.||.:::..|.....|..
  Fly   131 QEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKL 195

Human   178 INVGNINNDKKDEMYRSLFQDL-ELKKERRVILDCERDKVNDIVDQVITIGKHVKG-------YH 234
            .|:.:..:|     ||.|:::. |...|:|:|||||...:.:::.  ::|...::|       .|
  Fly   196 RNLADYADD-----YRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTH 253

Human   235 YIIANLGFTDGDLLKIQFGGANVSG--FQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTS 297
            ....|.|..  |:....| .||::.  .::||     .:.|..:.:.|.:.:....:.|.:   .
  Fly   254 LDTHNSGLR--DIYNEDF-KANITSVRLKVVD-----ANPFERKKTRLTKVDQILGNQTML---P 307

Human   298 ALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGL-----S 357
            .|.||||.:...:.||:    |...:..:..:.....:.||..|..|...:|.:..:.:     :
  Fly   308 ILIYDAVVLFASSARNV----IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKT 368

Human   358 GNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE---VDKMVVTLTELPSGNDTSGL--ENKTVV 417
            .|:|.|:.|:||::.:.|.:...|.|..:  |:.   :.|.::.| ||.|...|...  :.|...
  Fly   369 ENMKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNL-ELESAGTTQDFSEQRKVYT 430

Human   418 VTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV-GDGKYGARDADTKIW 481
            |.|..|.||.|||::||...|.|:||||.|||.:::::...|.|:..|| |:|||   :.:||.|
  Fly   431 VVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQW 492

Human   482 NGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEI 546
            :|::.:|:...|.|.:..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:
  Fly   493 DGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEV 557

Human   547 WMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQG 609
            |:.::||.:.:::....::|.|..||  .....:|..|.:     |.:.:.||.|..:|:.||||
  Fly   558 WIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----NIWNVNNSTWLMVGSIMQQG 617

Human   610 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSG 674
            |||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|
  Fly   618 CDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGG 682

Human   675 STKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC 739
            ||..||..|....:.:.|..|:...||.|..|..||||||||.||.||:|:|:|...|..:|. |
  Fly   683 STSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-C 746

Human   740 DTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEK 804
            |..::|..:..|.||:|.|.||..||.:::::|:|||:|.|.|:|||||  |......||..:..
  Fly   747 DLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWW--KNHNVTCDSYHEVD 809

Human   805 TSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK---------------SRAE---AKRMKVAKN 851
            ...||:..:.|||.:|.||:.:.:::.:.||.:.               .:||   |.:..|.|.
  Fly   810 GDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKK 874

Human   852 AQNINPSSSQNS 863
            ...|:.||.::|
  Fly   875 PMRISSSSDKSS 886

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 94/406 (23%)
PBP2_iGluR_AMPA 413..794 CDD:270433 161/383 (42%)
Glutamate binding 499..501 0/1 (0%)