back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIA2 and Ir25a

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	265/1009 - (26%)
Similarity:	428/1009 - (42%)	Gaps:	267/1009 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     9 VLLSP----VLW--GLIFGVSSNSIQIGG--------LFPRGADQEYSAFRVGMVQF---STSEF 56
            :|::|    :||  |.:..:||.|::|..        ||....|.|.:|..|.:|..   ....:
  Fly     2 ILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRY 66

Human    57 RLTPHIDNLEVANSFA--VTNAFCSQFSRGVYAIFGFYDKKSV--------------NTITSFCG 105
            .|:..:|::|...|.|  :..|.|::::..:       :||..              .|:.||..
  Fly    67 GLSVQLDSIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVKSFTQ 124

Human   106 TLHVSFITPSFPTDG-----------THPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDR 156
            .|.:..|:.|:...|           ...:::|:.|.   :..|:.|::.:......|.|||
  Fly   125 ALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD--- 186

Human   157 GLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVIL----DCERDKVN 217
                     ||..                  .|..|:||.|:::   .|.||.    |.:|::..
  Fly   187 ---------DSFV------------------MDHKYKSLLQNIQ---TRHVITAIAKDGKREREE 221

Human   218 DI-------VDQVITIG---------KHVK--------GYHYIIANLG--FTDGDLLKIQFGGAN 256
            .|       ::....:|         :.||        .:|.|..|.|  .:..|...|.|
  Fly   222 QIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMF---- 282

Human   257 VSGFQIVDYDD---------------SLVSKF-----IERWSTLEEKEYPGAHTTTIKYTSALTY 301
            :.......|.|               .|.|.|     :..:.|::|....||....::|   |..
  Fly   283 MKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEY---LNC 344

Human   302 DAVQVMTEAFRN--LRKQRIEISRRGNAG--DCLANPAVPWG--QGVEIERALKQVQVEGLSGNI 360
            |..|......||  ||....:|:...:.|  |.:.....|:.  ..::.|..:..:|:.|
  Fly   345 DDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRG----- 404

Human   361 KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVV-------- 417
                 |..:|            .:.||.|                  .|||.::.:|
  Fly   405 -----GSSVN------------SKSIGKW------------------ISGLNSELIVKDEEQMKN 434

Human   418 --------VTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR 474
                    :.|::::|::|..:.     ..:.|:|||:||..|||....|.|.:..|.|||:|..
  Fly   435 LTADTVYRIFTVVQAPFIMRDET-----APKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNM 494

Human   475 DADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSF 538
            |.:.: |||:|.:|:..:|||.:..:::...||.||||:.|:..| ||:||:::| .|...:|.|
  Fly   495 DENGQ-WNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKF 557

Human   539 LDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGRETQSSESTNEFGIFNSLWFS 601
            |..|...:|:||:.||...|.::::..|:|||.:  :.|:::|      .|...||.:...|||.
  Fly   558 LTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD------DEEKREFNLKECLWFC 616

Human   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEI 666
            :.:...||...:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:||:||.:|
  Fly   617 MTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKI 681

Human   667 AYGTLDSGSTKEFF--------------------------RRSKIAVFD--------KMWTYMRS 697
            .|..|:..|...:|                          .|||:||:|        |||..|:.
  Fly   682 LYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQE 746

Human   698 AE-PSVFVRTTAEGVARVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 759
            |: |:    |..|.|||||.|...  :|:|.::|...|: |...||...||.....|.|.||..:
  Fly   747 AKLPA----TLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQ 806

Human   760 GSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 824
            ||.|:...|.|:|.|..:..|:|||.||| ...|..||....::::..:|:.|:.|||.::..|:
  Fly   807 GSHLKDQFNNAILTLLNKRQLEKLKEKWW-KNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGI 870

Human   825 GLAMLVALIEF-CYKSRAEAKRMKVAK-NAQNIN 856
            |:|.:..:.|: .|:.|...:.:.||: ||:..|
  Fly   871 GMACITLVFEYWWYRYRKNPRIIDVAEANAERSN 904

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.