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Protein Alignment GRIA2 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	257/899 - (28%)
Similarity:	409/899 - (45%)	Gaps:	136/899 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     9 VLLSPVLWGLIFGVSS--NSIQIGGLFPRGADQEYSAFR-----VGMVQFSTSE--FRLTPHIDN 64
            :||...:|...|...|  ..|.||..|   .|.|....:     |..:....||  .|..|.|..
  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFF---YDDELELEKEFMTVVNAINGPESEQTMRFYPLIKR 66

Human    65 LEVAN-SFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG------TH 122
            |:..: |..:....|.....||.||||...|.:.:.:...|.:..:..|......:|      .|
  Fly    67 LKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH 131

Human   123 PFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSD--RGLSTLQAVLDSAAEKKWQVTAINVGN 182
            ...:.:.|.   |..|...:::.:.|.||..:||:|  |..:.||.:|             .:..
  Fly   132 QMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLL-------------QLRE 183

Human   183 INND-------KKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL 240
            ::||       .||:.:|.:::  .::.||||:||||.:.:.::::.....|...:..|..:.||
  Fly   184 VHNDVVRVRKFHKDDDFRVMWK--SIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL 246

Human   241 -GFT--------DGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTT---TI 293
             .:|        |.:...:....|.:    :|:.|....|             .|..:.|   .|
  Fly   247 ETYTDHLEELAADNETFAVNITAARL----LVNPDPPPYS-------------LPYGYVTQRDNI 294

Human   294 KYTSA---------LTYDAVQVMTEAFRN---LRKQRIEISRRGNAGDCLANPAVPWGQGVEIER 346
            .|.|:         |.:||:|:..:::||   ....|:.:.|  ...|..|:....|..|..:.|
  Fly   295 VYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLAR 357

Human   347 ALKQVQVEGLSG---------NIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL 402
            .:|     |.||         .::||::|:||.:.|.:             :..:|.:.:.:.:
  Fly   358 LMK-----GTSGVNNTNFRTSILQFDEDGQRITFNIEV-------------YDPLDGIGIAIWD- 403

Human   403 PSGN------DTSGLENKTVVVTTILESPYVMMKKN-HEM-LEGNERYEGYCVDLAAEIAKHCGF 459
            |.|.      |....:.....|.|.:..||....:. .|: |.||..|:||.|||...||:|.||
  Fly   404 PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGF 468

Human   460 KYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524
            :|....|.|.:||..|.:||.|||::||::...|.:.|..||||..|:..:||:.|||.||:||:
  Fly   469 EYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSIL 533

Human   525 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEFEDGRETQSS 586
            ..|....:..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|.... ...|:.:..
  Fly   534 AYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDWENPH-PCNRDPEVL 594

Human   587 ESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 651
            |  |::.|.|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|.
  Fly   595 E--NQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKME 657

Human   652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRK 716
            ..|.:.:|||.|.::.:||:..|||......|...|:...:..|.:.:||.:.:...|||.||||
  Fly   658 GSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRK 722

Human   717 SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLD 781
            ::|.|.:|:|:|..|| .:.:.||...||.....|.|.||.|.|:..|:.:::|:|||||:|.|.
  Fly   723 NRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELY 786

Human   782 KLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835
            .||.|||.:. .....:....:.|..::...:.|:||.|..|:.:|.|:.:.||
  Fly   787 DLKQKWWKNP-NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.