DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIA2 and Ir21a

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_001097043.1 Gene:Ir21a / 33157 FlyBaseID:FBgn0031209 Length:842 Species:Drosophila melanogaster


Alignment Length:698 Identity:138/698 - (19%)
Similarity:248/698 - (35%) Gaps:206/698 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   341 GVEIERALKQVQVEGLSGNIKFDQNGKRINYTINI---------------MELKTNGPR------ 384
            |:.:|...|.:.:....|.|..|...|...:|.:|               |..|..||:      
  Fly   127 GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVV 191

Human   385 ---KIGYW-------SEVDKMVVTLTELPSGND-------------------TSGLENKTVVVTT 420
               :...|       ||:...:|.|  |..|..                   ..||.:.|.||.|
  Fly   192 LVSRSTQWRLRDFLSSELSSNIVNL--LVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLT 254

Human   421 -----ILESPYVMMKKN--------HEM----------------LE----GNERYEGYCVDLAAE 452
                 .|..|::.:..:        |..                |:    |..|::|....|...
  Fly   255 SWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTM 319

Human   453 IAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFM 517
            |:|...|...:|     :...|.....:.:.:..:::....||.::.:.||  :|.::|.:   |
  Fly   320 ISKRLNFSIDIT-----ETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA---M 374

Human   518 SLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVVLF--------LVSRFSP 569
            |:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..::|        |:..:..
  Fly   375 SVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE 439

Human   570 YE---WHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTL 631
            .|   |:.                 ||:|.:.:...|.:...    :.|..|.|::.|.:|.||:
  Fly   440 VENMFWYV-----------------FGMFTNAFSFTGKYSWS----NTRKNSTRLLIGAYWLFTI 483

Human   632 IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMR 696
            ||.|.||.::.||:|:......::|..|| .......|||::|..:.:|:.|......:::..|.
  Fly   484 IITSCYTGSIIAFVTLPAFPDTVDSVLDL-LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME 547

Human   697 SAEPSVFVRTTAEGVARVRKS-KGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG-------- 752
                  ||.:..||:..|.:| ...||:|......||:.|....|.     |:..:.        
  Fly   548 ------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSALHLSEEC 601

Human   753 -----YGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNK--WWYDKGECG----AKDSGSK---- 802
                 .|...|:.|..:..::..:|...:.|::.|:.|:  |...:...|    |..|.|.    
  Fly   602 FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREII 666

Human   803 EKTSALSLSNVAGVFYILVGG--LGLAMLVA------------LIEFCYKSRA------------ 841
            ::...|:.::..|:|.::..|  ||...||:            :|:...||.|            
  Fly   667 QEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSML 731

Human   842 ------------EAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYG 877
                        :|.|.:.|:.||.::....:.:...||.:|.|..||
  Fly   732 RTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYG 779

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 16/87 (18%)
PBP2_iGluR_AMPA 413..794 CDD:270433 89/445 (20%)
Glutamate binding 499..501 0/1 (0%)