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Protein Alignment GRIA2 and Ir8a

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	153/569 - (26%)
Similarity:	274/569 - (48%)	Gaps:	88/569 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   369 INYTINIM--------ELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESP 425
            :.:.:||.        |.||:    :..||.|.:|.:.       |:|.....:...:.|....|
  Fly   342 LTFAVNISAGYYSSEHEAKTD----LAAWSSVGEMRLL-------NETISPARRFFRIGTAESIP 395

Human   426 YVMMKKNH---EML---EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGM 484
            :..:::..   |::   .|...:||||:|....:::...|::::.....|..|..: :...|:|:
  Fly   396 WSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELN-ELGEWDGV 459

Human   485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548
            ||:||.|:.|.|||.|.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:
  Fly   460 VGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWL 523

Human   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS--ESTNEFGIFNSLWFSLGAFMQQGCD 611
            .||.|.:|.:::::.:.::|||        ..|..:.:  .:..||.:..|.||:|.:|..||..
  Fly   524 SIVAALVGTAIMIWFMDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGG 580

Human   612 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGST 676
            .:|:::|||::...:|.|.:::::::|||||||||||||.:|::|.|.|::|:.|.|..:....|
  Fly   581 EAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDT 645

Human   677 KEFFRRSKIAV-----------------FDK--MWTY------------MRSAEPSVFVRTTAEG 710
            .::|...|.|.                 |.|  :|.|            :.|::|   |....||
  Fly   646 HQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEG 707

Human   711 VARV-RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKL 774
            .|.| ......||::.:|...:| |..:.|:..:||.....:.|.:|..:||.|...::.|:|:|
  Fly   708 FANVDAHENADYAFIHDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILEL 771

Human   775 SEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE-FCYK 838
            .:....::||.|:|   .:....:....|....::|.::.|||...:.||.|||:...:| ..||
  Fly   772 QKDRFFEELKAKYW---NQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYK 833

Human   839 SRAEAKRMKVAKNAQNINPSSSQNSQN-------FATYKEGYNVYGIES 880
            .:..|..:   ...:.:|.||.....:       .:|.|:.:::..:|:
  Fly   834 KKQNALEI---TQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEA 879

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.