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Protein Alignment GRIA2 and GluRIIE

DIOPT Version :9

Sequence 1:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	291/928 - (31%)
Similarity:	469/928 - (50%)	Gaps:	117/928 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    14 VLWGLI-------------FGVSSN-----SIQIGGLFPRGADQEYSAF----RVGMVQFSTSEF 56
            :||.|.             ||...|     |:.||.|..:..:|....|    .|...:..||
  Fly     8 ILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTS-- 70

Human    57 RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT 121
             ||...:.:...:::......|.....|:..:||...:.:...:.|.|..:.:..|. |:.::..
  Fly    71 -LTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENA 133

Human   122 HPFVIQMRP-DLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NIN 184
            ..|.:...| ||..||.|||..:.|.:|.:||:|...|:.|..:.....:....:|.:... .:|
  Fly   134 EGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLN 198

Human   185 NDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLK 249
            .:     |:.:.:.:....:.|:::....:.:.:.::|...:|...:.|.|||.||.|...||.:
  Fly   199 GN-----YKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEE 258

Human   250 IQFGGANVSGFQIVDYDDSLVSKFIER--WSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFR 312
            .::..||::|.::...:...|.:.:.:  :.|.:::...|:...|::  .||||||||:..:..:
  Fly   259 YKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVE--MALTYDAVQLFAQTLK 321

Human   313 NLR--------KQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG--LSGNIKFDQNGK 367
            ||.        .||.|..|               ..|...:..::.:::..  |:|.|.|:.|.:
  Fly   322 NLPFKPMPQNCSQRTESVR---------------DDGSSFKNYMRTLRLTDRLLTGPIYFEGNVR 371

Human   368 RINYTINIMELKTNGPRKIGYWSE-----VDKMVVTLTELPSGNDTSGLENKT-VVVTTILESPY 426
            : .|.::::||:.:|..|:|.|.|     ..::..|..:..|.:::  |.||| :::.::...||
  Fly   372 K-GYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNS--LANKTFIILLSVPNKPY 433

Human   427 VMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK-YGARDADTKIWNGMVGELVY 490
            ..:.:.::.||||.:||||.|||..|:|...||.:  |.|..|. ||:.:..|....||:.|::.
  Fly   434 AQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREIMT 496

Human   491 GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 555
            |:||:||..||||..||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::
  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFL 561

Human   556 GVSVVLFLVSRFSPYEWHT-----EEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPR 615
            |||:..|::.|.||.||..     ||.|        |..|:|.:.||:||:.||.:|||.:|.|:
  Fly   562 GVSLSFFILGRLSPSEWDNPYPCIEEPE--------ELENQFTLGNSIWFTTGALLQQGSEIGPK 618

Human   616 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTE-IAYGTLDSGSTKEF 679
            :||.|.|...|||||||::||||||||||||:|:..|.|.|.:||:...: :.||...:|||:.|
  Fly   619 ALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNF 683

Human   680 FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 744
            |..|....:.||..:| |..|........|||.|| |:...||:|:|||..||..:|: |:..|:
  Fly   684 FMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKKI 745

Human   745 GGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGE--CGAKDSGSKEKTSA 807
            |..||.||||||..|....|...|.|:|:|.|||||:|:|||||.:.|.  |..|:..  ...:.
  Fly   746 GDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDA--PDATP 808

Human   808 LSLSNVAGVFYILVGGLGLAMLVALIE---FCYKS--------RAEAKR-----------MKVAK 850
            |.::|:.|||::|:.|...|:|..:|.   |..|.        |...|.           ::|.|
  Fly   809 LDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLK 873

Human   851 NAQNINPSSSQNSQNFAT 868
            |:.:|...|.|:|.:.|:
  Fly   874 NSASIYSRSRQSSMSVAS 891

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.