Protein Alignment GRIA2 and Ir7b

DIOPT Version :10

• Sequence 1: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Sequence 2: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 824
• Identity: 150/824 - (18%)
• Similarity: 255/824 - (30%)
• Gaps: 313/824 - (37%)

Human   131 DLKGALLSLIEYYQWDKF--AYLYDSDRGLST---LQAVLDSAAEKKWQVTAINVGNINNDKKDE 190
            ||..||..::...:..:|  .|:|......||   |:.:||       ||..|...|:
  Fly    25 DLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLD-------QVLMIVPNNL------- 75

Human   191 MYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA 255
                        :.||::|.                 :.::...|:.|.|...|| |..:....|
  Fly    76 ------------QARRLLLQ-----------------QSMEYKPYVHAVLALVDG-LPSLSAIYA 110

Human   256 NVSGFQIVDYDDSLV----------------SKFIERWSTLE---EKEYPGAHTTTIKY------ 295
            .:...|  |...:|:                .:|:.|.|.|.   ....||.|...:.|
  Fly   111 RIRATQ--DLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSAL 173

Human   296 -----TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLAN-------PAVPW-----GQGVE 343
                 .||...:..||.|:.:.:   |....|:.||...||..       |.:.|     |..|.
  Fly   174 HGCQVISANVVNRYQVGTKRWAS---QDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVG 235

Human   344 IERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT 408
            ||.||.|...|.|             |:|:.:            ||.
  Fly   236 IEGALLQFMAENL-------------NFTVGL------------YWM------------------ 257

Human   409 SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473
                ||..|:.|..||..:.           :...|:..|.:..     ||.:|.: .|
  Fly   258 ----NKEEVLATFDESGRIF-----------DEIFGHHADFSLG-----GFHFKPS-AG------ 295

Human   474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 538
                        .|:.|.::                   :..|||   .||:....:|....:..
  Fly   296 ------------SEIPYSQS-------------------TYYFMS---HIMLVTNLQSAYSAYEK 326

Human   539 LD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HTEEFEDGRETQSSESTNEFGIFNSLWFS 601
            |. |....:|..|....|...::|.|:.|     | |..|.          ..|.:  :..|..:
  Fly   327 LSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHEL----------PRNPY--YELLVLT 374

Human   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLSKQTE 665
            :|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.:: :|.|::...
  Fly   375 MGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFT 437

Human   666 IAYGTLD-------------------SGSTKEFF--------RRSKIAVFD--KMWTYMRSAEP- 700
            |....::                   .||..:.|        ..:::|:..  :.:.|.|...|
  Fly   438 IQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPM 502

Human   701 ---------SVFVRTTAEGVAR------VRKSKGKYAY---LLESTMNEYIEQRKPCDTMKVGGN 747
                     .::.:..|..|.|      |...:.::|:   .||....:|:..
  Fly   503 SRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSA------------ 555

Human   748 LDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKE-----KTSA 807
            :|.|...:|....:|..|              ||.:       .|:....:|...:     :.:.
  Fly   556 VDEKDESVARIASTSYST--------------LDGI-------DGDPSLSESEEDQQVAPVRQNV 599

Human   808 LSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMK 847
            ||:..:|.:|: ||...|| |::|.::|..   .|.|...::||
  Fly   600 LSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	63/313 (20%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	71/431 (16%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877
Ir7b	NP_572410.2	None