DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRIA2 and Ir7b

DIOPT Version :9

Sequence 1:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens
Sequence 2:NP_572410.2 Gene:Ir7b / 31690 FlyBaseID:FBgn0029965 Length:655 Species:Drosophila melanogaster


Alignment Length:824 Identity:150/824 - (18%)
Similarity:255/824 - (30%) Gaps:313/824 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   131 DLKGALLSLIEYYQWDKF--AYLYDSDRGLST---LQAVLDSAAEKKWQVTAINVGNINNDKKDE 190
            ||..||..::...:..:|  .|:|......||   |:.:||       ||..|...|:       
  Fly    25 DLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLD-------QVLMIVPNNL------- 75

Human   191 MYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA 255
                        :.||::|.                 :.::...|:.|.|...|| |..:....|
  Fly    76 ------------QARRLLLQ-----------------QSMEYKPYVHAVLALVDG-LPSLSAIYA 110

Human   256 NVSGFQIVDYDDSLV----------------SKFIERWSTLE---EKEYPGAHTTTIKY------ 295
            .:...|  |...:|:                .:|:.|.|.|.   ....||.|...:.|      
  Fly   111 RIRATQ--DLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSAL 173

Human   296 -----TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLAN-------PAVPW-----GQGVE 343
                 .||...:..||.|:.:.:   |....|:.||...||..       |.:.|     |..|.
  Fly   174 HGCQVISANVVNRYQVGTKRWAS---QDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVG 235

Human   344 IERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT 408
            ||.||.|...|.|             |:|:.:            ||.                  
  Fly   236 IEGALLQFMAENL-------------NFTVGL------------YWM------------------ 257

Human   409 SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473
                ||..|:.|..||..:.           :...|:..|.:..     ||.:|.: .|      
  Fly   258 ----NKEEVLATFDESGRIF-----------DEIFGHHADFSLG-----GFHFKPS-AG------ 295

Human   474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 538
                        .|:.|.::                   :..|||   .||:....:|....:..
  Fly   296 ------------SEIPYSQS-------------------TYYFMS---HIMLVTNLQSAYSAYEK 326

Human   539 LD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HTEEFEDGRETQSSESTNEFGIFNSLWFS 601
            |. |....:|..|....|...::|.|:.|     | |..|.          ..|.:  :..|..:
  Fly   327 LSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHEL----------PRNPY--YELLVLT 374

Human   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLSKQTE 665
            :|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.:: :|.|::...
  Fly   375 MGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFT 437

Human   666 IAYGTLD-------------------SGSTKEFF--------RRSKIAVFD--KMWTYMRSAEP- 700
            |....::                   .||..:.|        ..:::|:..  :.:.|.|...| 
  Fly   438 IQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPM 502

Human   701 ---------SVFVRTTAEGVAR------VRKSKGKYAY---LLESTMNEYIEQRKPCDTMKVGGN 747
                     .::.:..|..|.|      |...:.::|:   .||....:|:..            
  Fly   503 SRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSA------------ 555

Human   748 LDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKE-----KTSA 807
            :|.|...:|....:|..|              ||.:       .|:....:|...:     :.:.
  Fly   556 VDEKDESVARIASTSYST--------------LDGI-------DGDPSLSESEEDQQVAPVRQNV 599

Human   808 LSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMK 847
            ||:..:|.:|: ||...|| |::|.::|..   .|.|...::||
  Fly   600 LSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 63/313 (20%)
PBP2_iGluR_AMPA 413..794 CDD:270433 71/431 (16%)
Glutamate binding 499..501 0/1 (0%)